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MW 478.7 Da, Purity >99%. Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active.

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Images

Chemical Structure - PD 184352 (CI-1040) (DMSO solution), MEK1/2 inhibitor (AB146601), expandable thumbnail

Key facts

CAS number
212631-79-3
Purity
> 99%
Form
Liquid
Molecular weight
478.7 Da
Molecular formula
C17H14ClF2IN2O2
PubChem identifier
6918454
Nature
Synthetic

Alternative names

Recommended products

MW 478.7 Da, Purity >99%. Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active.

Key facts

Purity
> 99%
PubChem identifier
6918454
Biochemical name
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide
Biological description

Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active.

Canonical SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChI
InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
IUPAC name
2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - PD 184352 (CI-1040) (DMSO solution), MEK1/2 inhibitor (ab146601), expandable thumbnail

    Chemical Structure - PD 184352 (CI-1040) (DMSO solution), MEK1/2 inhibitor (ab146601)

    2D chemical structure image of ab146601, PD 184352 (CI-1040) (DMSO solution), MEK1/2 inhibitor

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Product protocols

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