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AB146592

PD 98059 (DMSO solution), MEK1 inhibitor

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(4 Publications)

MW 267.28 Da, Purity >98%. Inhibitor of MKK1 (MEK1). Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, AI838772, AW493413, Albendazole monooxygenase, Albendazole sulfoxidase, Antigen NY-CO-13, BCC7, BCD541, C-mpl ligand, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIC9, CYPIIIA3, CYPIIIA4, Cellular tumor antigen p53, Component of gems 1, Craf 1 transforming gene, Cyclooxygenase 3, included, Cyclooxygenase-1, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-PCN1, Dual specificity mitogen-activated protein kinase kinase 1, EC 1.14.99.1, ERK activator kinase 1, ERK-1, ERK-2, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ERT 2, ERT1, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, Extracellular signal related kinase 1, Extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, FLJ11090, FLJ92943, Gemin-1, Glucocorticoid inducible P450, HGNC6877, HLP, HS44KDAP, HUMKER1A, Insulin-stimulated MAP2 kinase, LFS1, MAP Kinase, MAP kinase 1, MAP kinase 2, MAP kinase 3, MAP kinase isoform p42, MAP kinase isoform p44, MAP kinase kinase 1, MAP kinase/Erk kinase 1, MAP2K1, MAPK, MAPK 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, MEKK 1, MGC104252, MGC112732, MGC126680, MGC149605, MGC20180, MGC88320, MGDF, MK01_HUMAN, MK03_HUMAN, MKCSF, MKK 1, MP2K1_HUMAN, MPL ligand, MPLLG, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, Megakaryocyte stimulating factor, Microsomal monooxygenase, Microtubule-associated protein 2 kinase, Mitogen Activated Protein Kinase Kinase 1, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Murine sarcoma 3611 oncogene 1, Mutant tumor protein 53, Myeloproliferative leukemia virus oncogene ligand, NF 25, NR3B1, Nifedipine oxidase, Nuclear receptor subfamily 3 group B member 1, OTTHUMP00000020135, OTTHUMP00000125198, OTTHUMP00000174538, OTTHUMP00000174541, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, Oncogene RAF1, P38, P41, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C2C, P450C3, P450IIC19, P450IIC9, P53_HUMAN, PCOX1, PGG/HS, PGH synthase 1, PGH1_HUMAN, PGHS-1, PHS 1, PRKM 2, PRKM 3, PRKM1, PRKMK 1, PTGHS, PTGS1, Partial COX1 proteins, included, Phosphoprotein p53, Prostaglandin G/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Protein Kinase Mitogen Activated 3, Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1), Quinine 3-monooxygenase, RP24-311F12.2, Raf proto oncogene serine threonine protein kinase, S-mephenytoin 4-hydroxylase, SCAN1, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMN1, SMN2, SMNT, SMN_HUMAN, Sarcoma 3611 oncogene, Steroid hormone receptor ERR1, Survival motor neuron protein, Survival of motor neuron 1, telomeric, T-BCD541, THCYT1, TRP53, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Thrombopoietin, Thrombopoietin nirs variant 1, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Xenobiotic monooxygenase, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hERR1, p42-MAPK, p44-ERK1, p44-MAPK, p53 tumor suppressor, protein kinase mitogen-activated kinase 1, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2, tumor antigen p55, vRaf1 murine leukemia viral oncogene homologue 1

1 Images
Chemical Structure - PD 98059 (DMSO solution), MEK1 inhibitor (AB146592)
  • Chemical Structure

Lab

Chemical Structure - PD 98059 (DMSO solution), MEK1 inhibitor (AB146592)

2D chemical structure image of ab146592, PD 98059 (DMSO solution), MEK1 inhibitor

Key facts

CAS number

167869-21-8

Purity

>98%

Form

Liquid

form

Molecular weight

267.28 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>3</sub>NO<sub>3</sub>

PubChem

4713

Nature

Synthetic

Biochemical name

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Biological description

Inhibitor of MKK1 (MEK1).

Canonical smiles

COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2

InChi

InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChiKey

QFWCYNPOPKQOKV-UHFFFAOYSA-N

IUPAC Name

2-(2-amino-3-methoxyphenyl)chromen-4-one

10 mM

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

Product protocols

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancers 14: PubMed36077661

2022

P2YR-Mediated PAK1 Activation Is Involved in ESM-1 Overexpression in RT-R-MDA-MB-231 through FoxO1 Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Hana Jin,Hye Jung Kim

Frontiers in endocrinology 13:928591 PubMed35992111

2022

Hyperglycemia aggravates ischemic brain damage ERK1/2 activated cell autophagy and mitochondrial fission.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Liu,Xiao Yang,Jianguo Niu,Changchun Hei

Journal of orthopaedic research : official publica 37:1387-1397 PubMed30644571

2019

Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin.

Applications

Unspecified application

Species

Unspecified reactive species

Litong Fan,Jiaqing Chen,Yanmeng Tao,Boon Chin Heng,Jiakuo Yu,Zheng Yang,Zigang Ge

Cellular physiology and biochemistry : internation 50:2390-2405 PubMed30423583

2018

Novel Zinc Finger Transcription Factor ZFP580 Facilitates All-Trans Retinoic Acid -Induced Vascular Smooth Muscle Cells Differentiation by Rarα-Mediated PI3K/Akt and ERK Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shuping Wei,Jingjing Zhang,Biao Han,Jianxun Liu,Xiaohui Xiang,Mei Zhang,Shihai Xia,Wencheng Zhang,Xizheng Zhang
View all publications

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