JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB218118

PD0332991, Cdk4/Cdk6 inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 447.5 Da, Purity >98%. Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.

Key facts

CAS number

571190-30-2

Purity

>98%

Form

Solid

form

Molecular weight

447.5 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>9</sub>N<sub>7</sub>O<sub>2</sub>

PubChem

5330286

Nature

Synthetic

Solubility

Soluble in DMSO

Biochemical name

Palbociclib

Biological description

Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.

Canonical smiles

CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C

InChi

InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)

InChiKey

AHJRHEGDXFFMBM-UHFFFAOYSA-N

IUPAC Name

6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one

style
left-column

Complementary Products

Biochemicals

AB285415

Ribociclib (LEE011)

  • 0
  • 0
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Reagents, Controls & Accessories

AB286850

Density Gradient Medium (Iodixanol)

Chemical Structure - Density Gradient Medium (Iodixanol) (AB286850)

  • 0
  • 0
Primary Antibodies

AB207607

Anti-HIF-2-alpha antibody [EPR19656]

RabMAb|Recombinant

Western blot - Anti-HIF-2-alpha antibody [EPR19656] (AB207607)

  • 0
  • 0
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2843 PD0332991. 2843-25 is the same size as the 25 mg size of ab218118.
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com