MW 447.5 Da, Purity >98%. Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.
1110033K02Rik, 6430598J10Rik, AAK1_HUMAN, AI327039, AP2 associated kinase 1, AP2-associated protein kinase 1, Adaptor-associated kinase 1, B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, B230344N16, BCL-1, BCL-1 oncogene, BIKe, BMP-2-inducible protein kinase, BMP2 inducible kinase, BMP2K, BMP2K_HUMAN, Beta-interferon, Bike kinase, C-2K, CCND1/FSTL3 fusion gene, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, CCND1/PTH fusion gene, included, CCND1_HUMAN, CCND2_HUMAN, CCND3_HUMAN, CD1, CDC-like kinase 1, CDC28/CDC2 like kinase, CDC2L4, CDK16_HUMAN, CDK17_HUMAN, CDK4 protein, CDK4_HUMAN, CDK6_HUMAN, CDK9_HUMAN, CK II, CK II alpha', CK2A2, CLK/STY, CLK1_HUMAN, CMM 3, CSK22_HUMAN, CTCL tumor antigen HD CL 09, CTCL-associated antigen HD-CL-09, Casein kinase 2 alpha prime polypeptide, Casein kinase II alpha' chain, Casein kinase II subunit alpha', Cdc2-related kinase, Cell division cycle 2-like protein kinase 4, Cell division kinase 4, Cell division protein kinase 16, Cell division protein kinase 17, Cell division protein kinase 4, Cell division protein kinase 6, Cell division protein kinase 9, Crk 2, Crk3, Cutaneous T cell lymphoma tumor antigen HD CL 09, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, Cyclin-dependent kinase 16, Cyclin-dependent kinase 17, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Cyclin-dependent kinase 9, CyclinD2, CyclinD3, Cyl 1, D11S287E, D3 type cyclin, DKFZp434K0614, DKFZp434P0116, DKFZp586E0820, DKFZp666H245, DKFZp686F03202, DKFZp686K16132, DPK, Dendritic cell-derived protein kinase, Dual specificity protein kinase CLK1, EC 2.7.1.37, EDPK, EPK 2, F52, FLJ23712, FLJ25931, FLJ31060, FLJ31808, FLJ39635, FLJ42882, FLJ43934, FLJ45252, Fibroblast interferon, G1 S specific cyclin D3, G1/S-specific cyclin-D1, G1/S-specific cyclin-D2, G1/S-specific cyclin-D3, HRIHFB2017, HSPC187, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JIK, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, KDS, KIAA0881, KIAA1048, KIAK0002, KPCD2_HUMAN, KPCD3_HUMAN, KRCT, Kinase from chicken homolog A, Kinase from chicken homolog C, MAP3K17, MAP3K18, MCPH12, MGC102758, MGC138170, MGC14458, MGC16211, MGC164568, MGC164570, MGC25109, MGC59692, MGC96956, MPPH3, MPSK, MPSK1, Melanoma cutaneous malignant 3, Myristoylated and palmitoylated serine/threonine-protein kinase, NU, PCTAIRE, PCTAIRE protein kinase 1, PCTAIRE-motif protein kinase 1, PCTAIRE-motif protein kinase 2, PCTGAIRE, PCTK1, PCTK2, PI(5)P 4-kinase type II gamma, PI42C_HUMAN, PIP4KII-gamma, PIP5K2C, PITALRE, PKCnu, PKD 3, PKL12, PLSTIRE, PRAD1, PRAD1 oncogene, PRK D3, PRKCN, PRKD 2, PSK, PSK-1, PSK-J3, PSK1 beta, Parathyroid adenomatosis 1, Phosphatidylinositol 4 phosphate 5 kinase, Phosphatidylinositol 4 phosphate 5 kinase type II gamma, Phosphatidylinositol-5-phosphate 4-kinase type II gamma, Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma, Pip4k2c, Prostate derived STE20 like kinase PSK, Prostate derived sterile 20 like kinase 1, Prostate-derived STE20-like kinase 1, Protein kinase C, Protein kinase C nu, Protein kinase C nu type, Protein kinase D2, Protein kinase D3, Protein kinase EPK 2, Protein kinase Krct, Protein kinase PKL12, Protein kinase cdc2-related PCTAIRE-2, Protein kinase expressed in day 12 fetal liver, Protein tyrosine kinase STY, STE20-like kinase, STK16_HUMAN, STQTL11, STY, Serine kinase, Serine threonine protein kinase, Serine/threonine kinase 16, Serine/threonine-protein kinase 16, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase D3, Serine/threonine-protein kinase PCTAIRE-1, Serine/threonine-protein kinase PCTAIRE-2, Serine/threonine-protein kinase PITALRE, Serine/threonine-protein kinase PLSTIRE, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase TAO3, TAK, TAO 1, TAO 2, TAO kinase 2, TAO kinase 3, TAOK2_HUMAN, TAOK3_HUMAN, TGF-beta-stimulated factor 1, TGFB stimulated factor 1, TSF-1, Tat associated kinase complex catalytic subunit, Thousand and one amino acid protein 2, Thousand and one amino acid protein 3, Thousand and one amino acid protein kinase, Transforming growth factor beta stimulated factor 1, Tyrosine protein kinase STK16, U21B31, UNQ2971/PRO7431, hKFC-A, hKFC-C, hPSK, mKIAA0881, nPKC-D2, nPKC-nu, p34 cdk4
MW 447.5 Da, Purity >98%. Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.
Soluble in DMSO.
Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.
This product is manufactured by BioVision, an Abcam company and was previously called 2843 PD0332991. 2843-25 is the same size as the 25 mg size of ab218118.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com