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MW 736.7 Da, Purity >96%. Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
Alternative names=AGTR2_HUMAN, AT 2, ATGR 2, Angiotensin II type-2 receptor, Angiotensin receptor 2, MRX 88, Type-2 angiotensin II receptor, angiotensin II receptor type 2
- CAS number
136676-91-0
- Purity
> 96%
- Form
Solid
- Molecular weight
736.7 Da
- Molecular formula
C35H34F6N4O7
- PubChem identifier
6604951
- Nature
Synthetic
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MW 736.7 Da, Purity >96%. Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
Alternative names=AGTR2_HUMAN, AT 2, ATGR 2, Angiotensin II type-2 receptor, Angiotensin receptor 2, MRX 88, Type-2 angiotensin II receptor, angiotensin II receptor type 2
Key facts
- CAS number
136676-91-0
- Purity
> 96%
- Form
Solid
- Molecular weight
736.7 Da
- Molecular formula
C35H34F6N4O7
- PubChem identifier
6604951
- Nature
Synthetic
- Biochemical name
PD 123319 ditrifluoroacetate
- Biological description
Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
- Canonical SMILES
CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
- Isomeric SMILES
CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
- InChI
InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)/t28-;;/m0../s1
- InChIKey
GPKQIEZLHVGJQH-ZXVJYWQYSA-N
- IUPAC name
(6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid;2,2,2-trifluoroacetic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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