MW 164.3 Da. Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.
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- Cardiovascular research 119:1265-12782022Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Ji Cho,Dong Gwang Lee,Jeong Woong Lee,Byungtae Hwang,Sung-Jin Yoon,Seon-Jin Lee,Young-Jun Park,Seung-Ho Park,Hee Gu Lee,Yong-Hoon Kim,Chul-Ho Lee,Jangwook Lee,Nam-Kyung Lee,Tae-Su Han,Hyun-Soo Cho,Jeong Hee Moon,Ga Seul Lee,Kwang-Hee Bae,Geum-Sook Hwang,Sang-Hak Lee,Sang J Chung,Sungbo Shim,Jaehyung Cho,Goo Taeg Oh,Young-Guen Kwon,Jong-Gil Park,Jeong-Ki MinPubMed 36534975
- Cancer gene therapy 30:22-372022CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia-Bin Wang,You-Xin Gao,Yin-Hua Ye,Tong-Xing Lin,Ping Li,Jian-Xian Lin,Qi-Yue Chen,Long-Long Cao,Mi Lin,Ru-Hong Tu,Ju-Li Lin,Ze-Ning Huang,Hua-Long Zheng,Jian-Wei Xie,Chao-Hui Zheng,Chang-Ming HuangPubMed 35999359
- Bioengineered 13:13689-137022022Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB) signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiakai Han,Qian Zheng,Yongxia Cheng,Yong Liu,Yuxin Bai,Bin Yan,Sufen Guo,Jianbo Yu,Xinxin Li,Chong WangPubMed 35707851
- Diabetology international 13:358-3712022Dietary obesity and glycemic excursions cause a parallel increase in STEAP4 and pro-inflammatory gene expression in murine PBMCs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSigfrid Casmir Shayo,Kazuma Ogiso,Shigeru Kawade,Hiroshi Hashiguchi,Takahisa Deguchi,Yoshihiko NishioPubMed 35463853
- The American journal of pathology 190:2417-24262020Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKento Tazawa et. al.PubMed 32919979
- Frontiers in cell and developmental biology 8:7842020Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTian Zhang et. al.PubMed 32903542
- Folia neuropathologica 58:166-1752020Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-κB pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Song,Qibing Huang,Zeli Zhang,Feng Li,Zhenkuan XuPubMed 32729295
- Life sciences 254:1177422020Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJung Eun Nam et. al.PubMed 32360619
- Stem cells (Dayton, Ohio) 38:261-2752019CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLijun Ding,Bianca Vezzani,Nusrat Khan,Jing Su,Lu Xu,Guijun Yan,Yong Liu,Ruotian Li,Anushri Gaur,Zhenyu Diao,Yali Hu,Zhongzhou Yang,W Reef Hardy,Aaron W James,Haixiang Sun,Bruno PéaultPubMed 31721342
- BMC neuroscience 20:282019The involvement of spinal annexin A10/NF-κB/MMP-9 pathway in the development of neuropathic pain in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiHong Sun et. al.PubMed 31208343
Key facts
- CAS number
- 5108-96-3
- Form
- Solid
- Molecular weight
- 164.3 Da
- Molecular formula
- C5H12N2S2
- PubChem identifier
- 517348
- Nature
- Synthetic
Alternative names
15-PGDH, 15-hydroxyprostaglandin dehydrogenase [NAD+], AHD2, AL1A1_HUMAN, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH, liver cytosolic, ALDH-E1, ALHDII, Acetaldehyde dehydrogenase 1, Aldehyde dehydrogenase, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase liver cytosolic, HEL-S-53e, Hpgd, Hydroxyprostaglandin dehydrogenase 15 (NAD), MGC2318, NAD+ dependent 15 hydroxyprostaglandin dehydrogenase, OTTHUMP00000218960, OTTHUMP00000219016, OTTHUMP00000219018, PGDH1, PGDH_HUMAN, PHOAR1, PUMB 1, Prostaglandin dehydrogenase 1, RALDH 1, Retinal dehydrogenase 1, SDR36C1, Short chain dehydrogenase/reductase family 36C member 1, cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e
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MW 164.3 Da. Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.
Key facts
- CAS number
- 5108-96-3
- Form
- Solid
- Molecular weight
- 164.3 Da
- Molecular formula
- C5H12N2S2
- PubChem identifier
- 517348
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- Ammonium pyrrolidine-1-carbodithioate
- Biological description
Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.
- Canonical SMILES
- C1CCN(C1)C(=S)[S-].[NH4+]
- InChI
- InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
- InChIKey
- MDDIUTVUBYEEEM-UHFFFAOYSA-N
- IUPAC name
- azanium;pyrrolidine-1-carbodithioate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ALDH1A1 also known as aldehyde dehydrogenase 1 family member A1 has a mass of approximately 54 kDa. This enzyme catalyzes the oxidation of aldehydes to carboxylic acids using NAD+ as a cofactor. ALDH1A1 plays an important role in retinoic acid biosynthesis which is important for cellular differentiation and development. This protein is expressed in a variety of tissues including the liver kidney and stem cells where it is an important marker for stem cell identification. ALDH1A1 is sometimes discussed in conjunction with 15-prostaglandin dehydrogenase (15-PGDH) due to their roles in cellular processes.
- Biological function summary
ALDH1A1 participates in the detoxification of aldehydes protecting cells from oxidative stress. It is a part of the aldehyde dehydrogenase family which acts collectively to maintain cellular homeostasis. ALDH1A1 contributes to the metabolism of retinoids an essential process for stem cell differentiation and proliferation. Its activity in regulating retinoic acid levels impacts numerous biological processes supporting the conversion of vitamin A into active metabolites that affect cellular function.
- Pathways
ALDH1A1 is an important player in the retinoic acid signaling pathway and the alcohol metabolism pathway. Its role in the retinoic acid signaling pathway influences gene expression involved in growth and development. ALDH1A1 works alongside retinol binding proteins and interacts with the CYP26 family of enzymes which are responsible for retinoic acid catabolism. In the alcohol metabolism pathway ALDH1A1 functions alongside alcohol dehydrogenase to process ethanol and other alcohols preventing the accumulation of toxic aldehydes.
- Associated diseases and disorders
ALDH1A1 has associations with various cancers and neurodegenerative diseases. The enzyme's role in detoxifying reactive aldehydes links it to protection against neurodegenerative disorders like Parkinson's disease where oxidative stress plays a part in neurodegeneration. In cancers ALDH1A1 functions as a cancer stem cell marker implicating it in carcinogenesis and tumor progression. The enzyme’s interaction with other proteins such as 15-PGDH further emphasizes its importance in disease contexts where inflammatory and oxidative stress pathways are involved.
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Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)
2D chemical structure image of ab141406, PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant
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