Perifosine, Akt inhibitor

Key facts

CAS number

157716-52-4

Purity

>99%

Form

Solid

form

Molecular weight

462.7 Da

Molecular formula

C₂₅H₅₃NO₄P+

PubChem

148178

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Soluble in ethanol to 25 mM

Biochemical name

(1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate

Biological description

Alkylphospholipid and Akt inhibitor. Antiproliferative activity in vitro (IC₅₀ = 0.6 - 8.9 μM). Anticancer activity in vivo. Orally active.

Canonical smiles

CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C

InChi

InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1

InChiKey

SZFPYBIJACMNJV-UHFFFAOYSA-O

IUPAC Name

(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate