PF-3758309

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MW 490.6 Da, Purity >98%. A potent small molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. It binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

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39 kDa protein kinase, 5 AMP activated protein kinase alpha 1catalytic subunit, 5 AMP activated protein kinase catalytic alpha 1 chain, 5' AMP activated protein kinase gamma 1 subunit, 5' AMP activated protein kinase subunit gamma 1, 5''-AMP-activated protein kinase subunit gamma-1, 5''-AMP-activated protein kinase subunit gamma-2, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 90 kDa ribosomal protein S6 kinase 6, AAKG, AAKG1_HUMAN, AAKG2_HUMAN, AAPK1_HUMAN, ACACA kinase, AI194361, AI450832, AL024255, AMP activated protein kinase noncatalytic gamma 1 subunit, AMP-activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha -1, AMPK, AMPK 1, AMPK alpha 1, AMPK alpha 1 chain, AMPK gamma 1 chain, AMPK gamma1, AMPK gamma2, AMPK subunit alpha-1, AMPK subunit gamma-1, AMPK subunit gamma-2, AMPKa1, AMPKg, Acetyl-CoA carboxylase kinase, Alpha-PAK, BMK 1 kinase, BMK-1, BTF2 p80, Basic transcription factor 2 80 kDa subunit, Beta PAK, Big MAP kinase 1, C130083N04Rik, CAK, CAK 1, CDK-activating kinase, CDK-activating kinase 1, CDK7_HUMAN, CDKN1A, CDKN7, CMH6, COFS 2, CXPD, Cell division protein kinase 7, Cyclin-dependent kinase 7, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC 2.7.11.1, EC 2.7.11.24, EM9, ERCC2_HUMAN, ERK-1, ERK-2, ERK-4, ERT 2, ERT1, Excision repair 2, Excision repair cross complementing rodent repair deficiency complementation, Excision repair cross complementing rodent repair deficiency, complementation group 2, Extracellular signal-regulated kinase 1, Extracellular signal-regulated kinase 2, Extracellular signal-regulated kinase 5, Gamma-PAK, H91620p, HCAK, HMG CoA reductase kinase, HMGCR kinase, HS44KDAP, HUMKER1A, Homolog of Xenopus MO15 Cdk activating kinase, Hydroxymethylglutaryl-CoA reductase kinase, Insulin-stimulated MAP2 kinase, KIAA1142, KIAA126, KS6A6_HUMAN, Kinase subunit of CAK, MAP kinase 1, MAP kinase 2, MAP kinase 3, MAP kinase 7, MAP kinase isoform p42, MAP kinase isoform p44, MAPK 1, MAPK 7, MGC102762, MGC126218, MGC126219, MGC33776, MGC57364, MGC8666, MK01_HUMAN, MK07_HUMAN, MO15, MO15, Xenopus, homolog of, MRX30, MRX47, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 7, OPHN3, OTTHUMP00000045860, OTTHUMP00000045861, OTTHUMP00000045862, OTTHUMP00000045863, OTTHUMP00000065906, OTTHUMP00000065907, OTTHUMP00000161795, OTTHUMP00000161796, Oligophrenin 3, P21 (CDKN1A) activated kinase 2, P21 (CDKN1A) activated kinase 3, P21 protein (Cdc42/Rac) activated kinase 1, P21 protein (Cdc42/Rac) activated kinase 3, P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related), P38, P39 Mo15, P41, P58, PAK alpha, PAK3beta, PAK65, PAK7, PAKgamma, PRKAA 1, PRKAG 1, PRKM 2, PRKM 3, PRKM 7, PRKM1, PROTEIN KINASE, MITOGEN-ACTIVATED, 7, Prkag2, Protein kinase AMP activated alpha 1 catalytic subunit, Protein kinase AMP activated gamma 1 non catalytic subunit, Protein kinase AMP activated gamma 2 non catalytic subunit, Ribosomal S6 kinase 4, Ribosomal protein S6 kinase 90kDa polypeptide 6, Ribosomal protein S6 kinase alpha-6, S6/H4 kinase, S6K-alpha-6, SNF1-like protein AMPK, SNF1A, STE20 homolog, yeast, STK-1, Serine threonine kinase Stk1, Serine/threonine protein kinase 1, Serine/threonine protein kinase MO15, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PAK 7, TFIIH 80 kDa subunit, TFIIH Basal Transcription Factor Complex Helicase Subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH basal transcription factor complex kinase subunit, TFIIH basal transcription factor complex p80 subunit, TFIIH p80, Tau-protein kinase PRKAA1, WPWS, XPDC, Xeroderma pigmentosum complementary group D, Xeroderma pigmentosum group D-complementing protein, bPAK, cb116, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), erk1/2, hPAK3, hormone sensitive lipase kinase, im:7154392, kinase AMPK alpha1, p21 activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 2, p21-activated kinase 1, p21-activated kinase 2, p21-activated kinase 4, p21-activated kinase 5, p21-activated kinase 6, p21-activated kinase 7, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), p41mapk, p42-MAPK, p44-ERK1, p44-MAPK, p65-PAK, p90-RSK 6, pp90RSK4, protein kinase, AMP-activated, noncatalytic gamma-1, protein tyrosine kinase ERK2, rps6ka6, wu:fa94c10