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AB273523

PF-573228

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MW 491.5 Da, Purity >98%. Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.
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Chemical Structure - PF-573228 (AB273523)
  • Chemical Structure

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Chemical Structure - PF-573228 (AB273523)

Chemical structure of PF-573228, 869288-64-2

Key facts

CAS number

869288-64-2

Purity

>98%

Form

Solid

form

Molecular weight

491.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>0</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub>S

PubChem

11612883

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

Biological description

Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.

Canonical smiles

CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4

InChi

InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)

InChiKey

HESLKTSGTIBHJU-UHFFFAOYSA-N

IUPAC Name

6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2819 PF-573228. 2819-50 is the same size as the 50 mg size of ab273523.

Protect from air.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Toxic, refer to SDS for further information.

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Product protocols

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Product promise

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