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AB120985

PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor

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MW 410.3 Da, Purity >99%. Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.

Also available in simple stock solutions (ab146728) - add 1 ml of water to get an exact, ready-to-use concentration.
1 Images
Chemical Structure - PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor (AB120985)
  • Chemical Structure

Lab

Chemical Structure - PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor (AB120985)

2D chemical structure image of ab120985, PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor

Key facts

CAS number

950912-80-8

Purity

>99%

Form

Solid

form

Molecular weight

410.3 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>2</sub>Cl<sub>2</sub>FN<sub>5</sub>

PubChem

51049607

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

PF-670462

Biological description

Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.

Also available in simple stock solutions (ab146728) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl

InChi

InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H

InChiKey

PSNKGVAXBSAHCH-UHFFFAOYSA-N

IUPAC Name

4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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