PFI-3, bromodomain and SMARCA4 inhibitor

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(4 Publications)

MW 321.4 Da, Purity >98%. Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (K_d = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.

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ATP-dependent helicase SMARCA4, BAF 190, BAF180, BAF190A, BRG1 protein, BRG1-associated factor 180, BRG1-associated factor 190A, BRM/SWI2 related gene 1, Brahma protein like 1, CG11375, Global transcription activator homologous sequence, Homeotic gene regulator, MGC156155, MGC156156, MRD16, Mitotic growth and transcription activator, Nuclear protein GRB1, OTTHUMP00000202149, OTTHUMP00000202150, OTTHUMP00000202151, OTTHUMP00000202153, OTTHUMP00000202163, PB1_HUMAN, Pbrm1, Polybromo-1D, Protein BRG-1, Protein brahma homolog 1, Protein polybromo-1, RTPS2, SMARC A4, SMCA4_HUMAN, SNF2, SNF2 like 4, SNF2-beta, SNF2B, SNF2L4, SNF2LB, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, SWI2, Sucrose nonfermenting like 4, Transcription activator BRG1, global transcription activator snf2l4, hPB1, hSNF2b, polybromo 1