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AB145191

PGP 4008, P-glycoprotein inhibitor

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MW 393.5 Da, Purity >93%. Selective P-glycoprotein inhibitor. Reverses Pgp mediated drug resistance in NCI/ADR cells. Shows synergistic effects with doxorubicin (ab120629) in vivo. .
1 Images
Chemical Structure - PGP 4008, P-glycoprotein inhibitor (AB145191)
  • Chemical Structure

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Chemical Structure - PGP 4008, P-glycoprotein inhibitor (AB145191)

2D chemical structure image of ab145191, PGP 4008, P-glycoprotein inhibitor

Key facts

CAS number

365565-02-2

Purity

>93%

Molecular weight

393.5 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>3</sub>N<sub>3</sub>O

PubChem

9821937

Nature

Synthetic

Solubility

Soluble in ethanol to 5 mM

Soluble in DMSO to 50 mM

Biochemical name

Unii-M7jjr8HX5D

Biological description

Selective P-glycoprotein inhibitor. Reverses Pgp mediated drug resistance in NCI/ADR cells. Shows synergistic effects with doxorubicin (ab120629) in vivo.

Canonical smiles

C1CN(C2=NC3=CC=CC=C3C(=C21)NC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5

InChi

InChI=1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30)

InChiKey

HVIAKQBMYMKWII-UHFFFAOYSA-N

IUPAC Name

N-(1-benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Primary Antibodies

AB170904

Anti-P Glycoprotein antibody [EPR10364-57]

RabMAb|Recombinant|KO Validated

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

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Primary Antibodies

AB172630

Anti-MRP2 antibody [EPR10998]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRP2 antibody [EPR10998] (AB172630)

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Biochemicals

AB144551

BATCP, HDAC6 substrate

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Biochemicals

AB120629

Doxorubicin hydrochloride, Topoisomerase II inhibitor

Chemical Structure - Doxorubicin hydrochloride, Topoisomerase II inhibitor (AB120629)

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