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MW 340.3 Da, Purity >95%. Irreversible calmodulin antagonist (IC50 ~ 80 μM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.

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Images

Chemical Structure - Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (AB144619), expandable thumbnail

Key facts

CAS number
63-92-3
Purity
> 95%
Form
Solid
Molecular weight
340.3 Da
Molecular formula
C18H22ClNO.ClH
PubChem identifier
5284441
Nature
Synthetic

Target data

Recommended products

MW 340.3 Da, Purity >95%. Irreversible calmodulin antagonist (IC50 ~ 80 μM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.

Key facts

Purity
> 95%
PubChem identifier
5284441
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 100 mM.

Biochemical name
Phenoxybenzamine hydrochloride
Biological description

Irreversible calmodulin antagonist (IC50 ~ 80 μM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.

Canonical SMILES
CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl
InChI
InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
InChIKey
VBCPVIWPDJVHAN-UHFFFAOYSA-N
IUPAC name
N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (ab144619), expandable thumbnail

    Chemical Structure - Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (ab144619)

    2D chemical structure image of ab144619, Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist

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Product protocols

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