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AB144619

Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist

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MW 340.3 Da, Purity >95%. Irreversible calmodulin antagonist (IC50 ~ 80 μM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.
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Chemical Structure - Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (AB144619)
  • Chemical Structure

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Chemical Structure - Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (AB144619)

2D chemical structure image of ab144619, Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist

Key facts

CAS number

63-92-3

Purity

>95%

Form

Solid

form

Molecular weight

340.3 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>2</sub>ClNO.ClH

PubChem

5284441

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Phenoxybenzamine hydrochloride

Biological description

Irreversible calmodulin antagonist (IC50 ~ 80 μM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable.

Canonical smiles

CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl

InChi

InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChiKey

VBCPVIWPDJVHAN-UHFFFAOYSA-N

IUPAC Name

N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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