MW 317.8 Da, Purity >98%. Potent, reversible, non-selective α antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
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- BioMed research international 2018:29259852018Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMingshuai Wang et. al.PubMed 29511675
- Redox biology 10:128-1392016The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAshleigh M Byrne et. al.PubMed 27744118
- Neuroscience 193:72-92011Nerve growth factor augments neuronal responsiveness to noradrenaline in cultured dorsal root ganglion neurons of rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQ Zhang et. al.PubMed 21784134
- Archives of pharmacal research 33:479-892010Phentolamine inhibits the pacemaker activity of mouse interstitial cells of Cajal by activating ATP-sensitive K+ channels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeung Whan Ahn et. al.PubMed 20361315
- Proceedings of the National Academy of Sciences of the United States of America 94:11716-201997Phentolamine block of KATP channels is mediated by Kir6.2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesP Proks,F M AshcroftPubMed 9326676
Key facts
- CAS number
- 73-05-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 317.8 Da
- Molecular formula
- C17H20ClN3O
- PubChem identifier
- 5702144
- Nature
- Synthetic
Alternative names
ADA1D_HUMAN, ADRA 1, ADRA1A, ADRA1R, Adra1d, Adrd1, Adrenergic alpha 1A receptor, Adrenergic alpha 1D receptor, Adrenergic receptor alpha 1d, Adrenergic receptor delta1, Adrenoceptor alpha 1D, Alpha-1, Alpha-1A adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a, Alpha1DAR, DAR, Gpcr8, RA42, Spr8, dJ779E11.2
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MW 317.8 Da, Purity >98%. Potent, reversible, non-selective α antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
- 73-05-2
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 317.8 Da
- Molecular formula
- C17H20ClN3O
- PubChem identifier
- 5702144
- Nature
- Synthetic
- Solubility
Soluble in water to 50 mM.
- Biochemical name
- Phentolamine hydrochloride
- Biological description
Potent, reversible, non-selective α antagonist.
- Canonical SMILES
- CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.Cl
- InChI
- InChI=1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H
- InChIKey
- TUEJFGFQYKDAPM-UHFFFAOYSA-N
- IUPAC name
- 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The alpha 1d adrenergic receptor also known as the alpha-1d adrenoceptor is a G-protein-coupled receptor with mass approximately 70 kDa. It plays a critical role in the modulation of physiological responses by binding catecholamines like norepinephrine and epinephrine. Alpha-1d adrenergic receptor is widely expressed in vascular smooth muscle heart liver and central nervous system. This receptor remains an important target for pharmacological research due to its involvement in various physiological processes.
- Biological function summary
The alpha-1d adrenergic receptor promotes vasoconstriction and increases blood pressure through the activation of phospholipase C pathway resulting in calcium release from intracellular stores. It functions as part of a receptor complex that interacts with other alpha-1 adrenergic subtypes such as alpha-1a and alpha-1b adrenergic receptors differentiating their roles in tissue-specific actions. These receptor activities affect muscle contraction and influence systemic vascular resistance.
- Pathways
This adrenergic receptor is engaged in the adrenergic signaling in cardiomyocytes and vascular smooth muscle contraction pathways. It facilitates communication between the signaling molecules and cellular responses. The alpha-1d adrenergic receptor partners with proteins like Gq/11 protein family which mediates signal transduction leading to its physiological effects. Interaction with other receptors such as beta-adrenergic receptors shapes the overall cardiovascular outcomes by providing a balance between constriction and relaxation.
- Associated diseases and disorders
The alpha-1d adrenergic receptor links to hypertension and benign prostatic hyperplasia where its modulation can influence disease progression and treatment outcomes. In hypertension dysregulation of alpha-1d adrenergic signaling may alter vascular tone and resistance contributing to elevated blood pressure. Connections with proteins such as phospholipase C confirm its involvement in the signaling cascade that affects these conditions. Modulation of this receptor activity offers therapeutic potential for related cardiovascular and urological disorders.
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Chemical Structure - Phentolamine hydrochloride, Non-selective alpha antagonist (ab120791)
2D chemical structure image of ab120791, Phentolamine hydrochloride, Non-selective alpha antagonist
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