Phorbol 12-myristate 13-acetate (PMA), PKC activator (DMSO solution)
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(4 Publications)
MW 616.8 Da, Purity >99%. Potent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non-kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter.
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14-3-3-zetaisoform, AI098070, Atypical protein kinase C-lambda/iota, C80388, CVID9, D14Ertd420e, DXS1179E, EC 2.7.11.13, EPK 2, KPCA_HUMAN, KPCB_HUMAN, KPCD1_HUMAN, KPCD3_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCI_HUMAN, KPCL_HUMAN, KPCT_HUMAN, KPCZ_HUMAN, Kinase PKC delta, May-01, MGC 5363, MGC125656, MGC125657, MGC126514, MGC141919, MGC26269, MGC26534, MGC49908, MGC57564, NU, OTTHUMP00000001368, OTTHUMP00000043364, OTTHUMP00000043365, OTTHUMP00000044160, OTTHUMP00000067291, PCKd, PKC, PKC 0, PKC 2, PKC MU, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC lambda, PKC lambda/iota, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PKCI, PKCM, PKCiota, PKCnu, PKD, PKD 3, PKM-zeta, included, PRK D3, PRKC D, PRKC delta, PRKC iota, PRKC-lambda/iota, PRKCA, PRKCB, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCI, PRKCL, PRKCM, PRKCN, PRKCT, PRKCZ, PRKD 1, Pkcea, Pkcz, Prkch, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C iota, Protein kinase C iota type, Protein kinase C mu, Protein kinase C mu type, Protein kinase C nu, Protein kinase C nu type, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Protein kinase C zeta form, Protein kinase C zeta type, Protein kinase D, Protein kinase D1, Protein kinase D3, Protein kinase EPK 2, R74924, SCA 14, Serine threonine protein kinase, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D3, Tyrosine protein kinase PRKCD, aPKC-lambda/iota, aPKCzeta, nPKC-D1, nPKC-delta, nPKC-epsilon, nPKC-eta, nPKC-iota, nPKC-mu, nPKC-nu, nPKC-theta, nPKC-zeta, r14-3-3, zetaPKC
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Publications (4)
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F1000Research 13:1049 PubMed40535171
2025
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Nature protocols 20:1509-1545 PubMed39690206
2024
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F1000Research 13:77 PubMed39429638
2024
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Cytotherapy 26:136-144 PubMed38149947
2023
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