JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB144638

Phortress, Antitumor agent

Be the first to review this product! Submit a review

|

(0 Publication)

MW 459.4 Da, Purity >98%. Potent antitumor agent (IC50 values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.
1 Images
Chemical Structure - Phortress, Antitumor agent (AB144638)
  • Chemical Structure

Lab

Chemical Structure - Phortress, Antitumor agent (AB144638)

2D chemical structure image of ab144638, Phortress, Antitumor agent

Key facts

CAS number

328087-38-3

Purity

>98%

Form

Solid

form

Molecular weight

459.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>5</sub>Cl<sub>2</sub>FN<sub>4</sub>OS

PubChem

9804228

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

CID 9804228

Biological description

Potent antitumor agent (IC50 values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.

Canonical smiles

CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)C(CCCCN)N.Cl.Cl

Isomeric smiles

CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)[C@H](CCCCN)N.Cl.Cl

InChi

InChI=1S/C20H23FN4OS.2ClH/c1-12-10-13(20-25-17-11-14(21)6-8-18(17)27-20)5-7-16(12)24-19(26)15(23)4-2-3-9-22;;/h5-8,10-11,15H,2-4,9,22-23H2,1H3,(H,24,26);2*1H/t15-;;/m0../s1

InChiKey

QZSMNTOCJVVFEU-CKUXDGONSA-N

IUPAC Name

(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide;dihydrochloride

style
left-column

Product details

Sold under license from CRT.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB15537

Anti-TGF beta 3 antibody

Western blot - Anti-TGF beta 3 antibody (AB15537)

  • 4
  • 5
Reagents, Controls & Accessories

AB7475

Normal Donkey Serum

Immunohistochemistry (PFA perfusion fixed frozen sections) - Normal Donkey Serum (AB7475)

  • 0
  • 0
Reagents, Controls & Accessories

AB7481

Normal Goat Serum

Immunohistochemistry (Frozen sections) - Normal Goat Serum (AB7481)

  • 5
  • 3
Reagents, Controls & Accessories

AB138478

Normal Goat Serum (Sterile)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com