MW 244.25 g/mol, Purity >99%. Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
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- Frontiers in immunology 12:6020672021S-Layer From Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMariano Prado Acosta,Guillaume Goyette-Desjardins,Jörg Scheffel,Anne Dudeck,Jürgen Ruland,Bernd LepeniesPubMed 33732234
- Antimicrobial agents and chemotherapy 61:2017Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChi N Chan et. al.PubMed 28652233
- Scientific reports 7:81202017NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYa-Qi Lu et. al.PubMed 28808303
- Scientific reports 7:28312017Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaisuke Muramatsu et. al.PubMed 28588201
Key facts
- CAS number
- 10083-24-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 244.25 g/mol
- Molecular formula
- C14H12O4
- Nature
- Synthetic
Recommended products
MW 244.25 g/mol, Purity >99%. Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
Key facts
- CAS number
- 10083-24-6
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 244.25 g/mol
- Molecular formula
- C14H12O4
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biological description
Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
- IUPAC name
- 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Piceatannol, Syk tyrosine kinase inhibitor (ab120722)
2D chemical structure image of ab120722, Piceatannol, Syk tyrosine kinase inhibitor
Functional Studies - Piceatannol, Syk tyrosine kinase inhibitor (ab120722)
ab119954 staining CBL in A431 cells treated with piceatannol (ab120722), by ICC/IF. Decrease in CBL expression correlates with increased concentration of piceatannol, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120722 (piceatannol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab119954 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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