JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120722

Piceatannol, Syk tyrosine kinase inhibitor

Be the first to review this product! Submit a review

|

(4 Publications)

MW 244.25 g/mol, Purity >99%. Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
2 Images
Functional Studies - Piceatannol, Syk tyrosine kinase inhibitor (AB120722)
  • FuncS

Unknown

Functional Studies - Piceatannol, Syk tyrosine kinase inhibitor (AB120722)

ab119954 staining CBL in A431 cells treated with piceatannol (ab120722), by ICC/IF. Decrease in CBL expression correlates with increased concentration of piceatannol, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120722 (piceatannol) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab119954 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Piceatannol, Syk tyrosine kinase inhibitor (AB120722)
  • Chemical Structure

Lab

Chemical Structure - Piceatannol, Syk tyrosine kinase inhibitor (AB120722)

2D chemical structure image of ab120722, Piceatannol, Syk tyrosine kinase inhibitor

Key facts

CAS number

10083-24-6

Purity

>99%

Form

Solid

form

Molecular weight

244.25 g/mol

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

Syk tyrosine kinase inhibitor (Ki = 15 μM at Syk). Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.

IUPAC Name

4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 12:602067 PubMed33732234

2021

S-Layer From Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Mariano Prado Acosta,Guillaume Goyette-Desjardins,Jörg Scheffel,Anne Dudeck,Jürgen Ruland,Bernd Lepenies

Antimicrobial agents and chemotherapy 61: PubMed28652233

2017

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene.

Applications

Unspecified application

Species

Unspecified reactive species

Chi N Chan,Benjamin Trinité,David N Levy

Scientific reports 7:8120 PubMed28808303

2017

NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Qi Lu,Shan Zhong,Nan Meng,Yin-Ping Fan,Wang-Xian Tang

Scientific reports 7:2831 PubMed28588201

2017

Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Daisuke Muramatsu,Mitsuyasu Okabe,Akinori Takaoka,Hiroshi Kida,Atsushi Iwai
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB1766

Anti-p55/DCAF1 antibody

  • 4
  • 2
Biochemicals

AB146624

GW2580 (DMSO solution), cFMS RTK inhibitor

Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (AB146624)

  • 0
  • 0
Biochemicals

AB143963

1-Palmitoyl-sn-glycero-3-phosphorylcholine

Chemical Structure - 1-Palmitoyl-sn-glycero-3-phosphorylcholine (AB143963)

  • 0
  • 0
Biochemicals

AB145864

INCA-6, calcineurin-NFAT interaction inhibitor

Chemical Structure - INCA-6, calcineurin-NFAT interaction inhibitor (AB145864)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com