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MW 602.6 Da, Purity >98%. Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant *in vivo*.


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Chemical Structure - Picrotoxin, GABAA antagonist (AB120315), expandable thumbnail

Publications

Key facts

CAS number
124-87-8
Purity
> 98%
Form
Solid
Source
Anamirta cocculus
Molecular weight
602.6 Da
Molecular formula
C15H18O7.C15H16O6
PubChem identifier
31304
Nature
Native

Target data

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MW 602.6 Da, Purity >98%. Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant *in vivo*.

Key facts

Purity
> 98%
Source
Anamirta cocculus
PubChem identifier
31304
Solubility

For more Solubility (Complete) data for PICROTOXIN (7 total), please visit the HSDB record page.

Soluble in DMSO to 100 mM.

Soluble in ethanol to 50 mM (with heating).

Biochemical name
Picrotoxin
Biological description

Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant *in vivo*.

Canonical SMILES
CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
Isomeric SMILES
CC(=C)[C@@H]1C2[C@@H]3[C@@]4([C@](C1C(=O)O2)(CC5[C@]4(O5)C(=O)O3)O)C.C[C@@]12[C@H]3C4[C@H](C([C@@]1(C[C@@H]5[C@]2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
InChI
InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
InChIKey
VJKUPQSHOVKBCO-ZTYBEOBUSA-N
IUPAC name
(1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Notes

5g pack supplied as 5x1g

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1 product image

  • Chemical Structure - Picrotoxin, GABAA antagonist (ab120315), expandable thumbnail

    Chemical Structure - Picrotoxin, GABAA antagonist (ab120315)

    2D chemical structure image of ab120315, Picrotoxin, GABAA antagonist

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Product protocols

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