Pifithrin-mu, Inhibitor of p53-mediated apoptosis

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MW 181.21 g/mol, Purity >98%. An inhibitor of p53-mediated apoptosis. Prevents p53 binding at the mitochondrial surface without affecting p53 transactivational activities. Pifithrin-μ reduces p53-mediated apoptosis triggered by nutlin; also interacts selectively with HSP70, disrupting its association with many substrate proteins.

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Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, FLJ92943, LFS1, Mutant tumor protein 53, P53_HUMAN, Phosphoprotein p53, TRP53, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, p53 tumor suppressor, tumor antigen p55