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MW 431.2 Da, Purity >98%. Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.

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Publications

Key facts

CAS number

1204531-26-9

Purity

> 98%

Form

Solid

Molecular weight

431.2 Da

Molecular formula

C15H15FIN3O3

PubChem identifier

44187362

Nature

Synthetic

Target data

Recommended products

MW 431.2 Da, Purity >98%. Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.

Key facts

Purity

> 98%

PubChem identifier

44187362

Biochemical name

Pimasertib

Biological description

Pimasertib (AS-703026) is a potent and selective ATP non-competitive inhibitor of MEK1 and MEK2. It displays an IC50 of 5 nM-2 μM in multiple myeloma cell lines. Growth and survival of U-266 and INA-6 is inhibited with IC50 of 5 nM and 11 nM, respectively. Induces apoptosis via caspase-3 and PARP cleavage in multiple myeloma cells. Inhibits the ERK pathway, proliferation, and transformation in human DLD-1 colorectal cancer cells what carry the D-MUT mutant allele of K-Ras.

Canonical SMILES

C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O

Isomeric SMILES

C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O

InChI

InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1

InChIKey

VIUAUNHCRHHYNE-JTQLQIEISA-N

IUPAC name

N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark, Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B1698 Pimasertib. B1698-25 is the same size as the 25 mg size of ab235569.

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