Pimobendan (Vetmedin), Ca2+ channel sensitizer
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MW 334.4 Da, Purity >99%. Ca2+ channel sensitizer. Selective PDE3 inhibitor. Inhibits platelet aggregation. Shows antithrombotic, antihypertensive, potent inotropic and vasodilatory effects *in vivo.* Orally active.
View Alternative Names
5''-cyclic phosphodiesterase A, 5''-cyclic phosphodiesterase B, AI847709, Adipocyte cAMP phosphodiesterase cGMP inhibited, CGI PDE, CGI-PDE A, CGI-PDE B, CGIP1, CGIPDE1, CGMP inhibited cAMP phophodiesterase, Cyclic GMP-inhibited phosphodiesterase A, Cyclic GMP-inhibited phosphodiesterase B, Cyclic nucleotide phosphodiesterase, HcGIP1, HcGIP1, rat, homolog of, Human cGMP inhibited cAMP phosphodiesterase mRNA, PDE3A_HUMAN, PDE3B_HUMAN, Phosphodiesterase 3A, Phosphodiesterase 3A cGMP inhibited, Phosphodiesterase 3B, Phosphodiesterase 3B cGMP inhibited, cAMP Phosphodiesterase, adipocyte, cGMP-inhibited, cAMP phosphodiesterase myocardial cGMP inhibited, cGMP inhibited 3 5 cyclic phosphodiesterase B, cGMP inhibited 3' 5' cyclic phosphodiesterase A, cGMP-inhibited 3''
- Chemical Structure
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Chemical Structure - Pimobendan (Vetmedin), Ca2+ channel sensitizer (AB143019)
2D chemical structure image of ab143019, Pimobendan (Vetmedin), Ca2+ channel sensitizer
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Properties and storage information
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Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Handling instructions
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These enzymes modulate the balance between cAMP and cGMP concentrations which in turn controls various physiological processes. PDE3A and PDE3B do not function as part of large multi-protein complexes but influence fundamental cellular responses like muscle contraction lipolysis and platelet aggregation. The regulation of cAMP and cGMP is important for their role in the cardiovascular and metabolic systems.
Pathways
These enzymes play a significant role in the cAMP signaling and cGMP signaling pathways. PDE3A is closely associated with cardiac function interacting with proteins like troponin and phospholamban to mediate cardiac contractility. On the other hand PDE3B influences insulin signaling pathways connecting with proteins involved in glucose and lipid metabolism. These connections highlight PDE3B's role in metabolic regulation and energy homeostasis.
Product promise
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