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AB120521

Pindolol, 5-HT1A and 5-HT1B receptor antagonist

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MW 248.32 Da, Purity >99%. 5-HT1A and 5-HT1B receptor antagonist (Ki and IC50 values are 8.9 and 6.8 nM at 5-HT1A and 5-HT1B receptors, respectively). Partial β3 adrenoceptor agonist (pEC50 = 5.11). Accelerates antidepressant effects of selective serotonin reuptake inhibitors (SSRIs).

View Alternative Names

5 HT 2B receptor, 5 HT(2B), 5 HT1DB, 5 HT2 receptor, 5 Hydroxytryptamine 2C receptor, 5 hydroxytryptamine (serotonin) receptor 1B, 5 hydroxytryptamine (serotonin) receptor 1D G protein coupled, 5 hydroxytryptamine (serotonin) receptor 2B, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled, 5 hydroxytryptamine 1A receptor, 5 hydroxytryptamine 1B receptor (5 HT 1B) (Serotonin receptor) (5 HT 1D beta) (Serotonin 1D beta receptor) (S12), 5 hydroxytryptamine 2B receptor, 5-HT-1C, 5-HT-1D-alpha, 5-HT-1D-beta, 5-HT-2, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5HT1B_HUMAN, 5HT1D_HUMAN, 5HT2A_HUMAN, 5HT2B_HUMAN, 5HT2C_HUMAN, 5HT2F, ADRB1R, ADRB1_HUMAN, ADRB2R, ADRB2RL1, ADRB2_HUMAN, ADRB3R, ADRB3_HUMAN, ADRBR, ADRBRL1, AGAL_HUMAN, Adrenergic beta 1 receptor, Adrenergic beta 2 receptor surface, Adrenergic beta 3 receptor, Adrenoceptor beta 1, Adrenoceptor beta 2 surface, Agalsidase alfa, Alpha D galactoside galactohydrolase 1, Alpha gal A, Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Alpha-galactosidase A, B1AR, B2AR, B3AR, BAR, BETA1AR, BETA2AR, Beta 3AR, Beta-1 adrenergic receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor, Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, Beta-3 adrenergic receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor, Catecholamine receptor, FLJ99960, G-21, GLA, GLA protein, Galactosidase, alpha, HT1DA, HTR 2, HTR 2A, HTR1D, HTR1D2, HTR1DA, HTR1DB, HTR2, formerly, HTR2C, HTRL, Htr 2b, Htr1b, Htr1c, Melibiase, NP75 protein, OTTHUMP00000160386, Oct-01, Organic cation transporter 1, RDC4, RHR, S22A1_HUMAN, SEROTONIN 5HT2B RECEPTOR, Serotonin 1D alpha receptor, Serotonin 1D beta receptor, Serotonin 5-HT-2C receptor, Serotonin receptor 1A, Serotonin receptor 1B, Serotonin receptor 1D, Serotonin receptor 2A, Serotonin receptor 2B, Serotonin receptor 2C, Slc22a1, Solute carrier family 22 member 1, Stomach fundus serotonin receptor, hOCT1, oct1_cds, serotonin 1c receptor, serotonin 2c receptor, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor, solute carrier family 22 (organic cation transporter), member 1

1 Images
Chemical Structure - Pindolol, 5-HT1A and 5-HT1B receptor antagonist (AB120521)
  • Chemical Structure

Lab

Chemical Structure - Pindolol, 5-HT1A and 5-HT1B receptor antagonist (AB120521)

2D chemical structure image of ab120521, Pindolol, 5-HT1A and 5-HT1B receptor antagonist

Key facts

CAS number

13523-86-9

Purity

>99%

Form

Solid

form

Molecular weight

248.32 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

4828

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Soluble in ethanol to 25 mM (with heating)

Biochemical name

Pindolol

Biological description

5-HT1A and 5-HT1B receptor antagonist (Ki and IC50 values are 8.9 and 6.8 nM at 5-HT1A and 5-HT1B receptors, respectively). Partial β3 adrenoceptor agonist (pEC50 = 5.11). Accelerates antidepressant effects of selective serotonin reuptake inhibitors (SSRIs).

Canonical smiles

CC(C)NCC(COC1=CC=CC2=C1C=CN2)O

InChi

InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChiKey

JZQKKSLKJUAGIC-UHFFFAOYSA-N

IUPAC Name

1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The targets beta 1 Adrenergic Receptor beta 2 Adrenergic Receptor and beta 3 Adrenergic Receptor are G protein-coupled receptors (GPCRs) recognized for modulating heart rate and muscle relaxation. Beta 1 and beta 2 receptors typically express in cardiac and pulmonary tissues with a mass of approximately 46 kDa each. The beta 3 Adrenergic Receptor however is more prevalent in adipose tissue and is involved in energy balance. The 5-HT receptors including 5-HT1B 5-HT1D 5-HT2A 5-HT2B and 5-HT2C interact with serotonin to influence mood cognition and perception. SLC22A1/OCT1 is an organic cation transporter present in the liver playing a role in drug clearance. Galactosidase alpha known for its lysosomal function with a role in glycosphingolipid metabolism expresses in various tissues notably within the central nervous system.
Biological function summary

These receptors and transporters modulate significant cellular processes. The adrenergic receptors regulate the sympathetic nervous system facilitating responses like vasodilation and bronchodilation. 5-HT receptors manage neurotransmitter pathways impacting mood and sensory processing. The SLC22A1/OCT1 transporter is important for drug absorption and metabolism affecting pharmacokinetics. Galactosidase alpha functions enzymatically within the lysosome as part of a larger enzyme complex that breaks down glycolipids.

Pathways

The adrenergic receptors engage in the adrenergic signaling pathway interacting with kinases and enzymes to modulate cardiovascular functions. The 5-HT receptors are integral to the serotonin signaling pathway influencing neurological and behavioral outcomes. The SLC22A1/OCT1 operates within the hepatic clearance pathways affecting the metabolism of various therapeutic compounds. The function of Galactosidase alpha ties into the lysosomal degradation pathway connected with enzymes like ceramide trihexosidase.

The adrenergic receptors associate with cardiovascular diseases such as hypertension and heart failure often targeted by drugs like pindolol for therapeutic management. Dysregulation of 5-HT receptors links to psychiatric disorders including anxiety and depression as these receptors modulate serotonin’s impact on the brain. Deficiencies in Galactosidase alpha are known to cause Fabry disease a lysosomal storage disorder affecting multiple organs. Pindolol a non-selective beta-blocker interacts with these adrenergic systems offering insights into therapeutic strategies for managing hypertension and anxiety-related disorders.
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Product protocols

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