JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141425

Pirfenidone, orally active anti-inflammatory antifibrotic agent

Be the first to review this product! Submit a review

|

(1 Publication)

MW 185.22 Da, Purity >99%. Orally active anti-inflammatory, antifibrotic and antiproliferative agent. Blood-brain barrier permeable. Shown to modulate cytokines TGF-β and TNF-α.
1 Images
Chemical Structure - Pirfenidone, orally active anti-inflammatory antifibrotic agent (AB141425)
  • Chemical Structure

Lab

Chemical Structure - Pirfenidone, orally active anti-inflammatory antifibrotic agent (AB141425)

2D chemical structure image of ab141425, Pirfenidone, orally active anti-inflammatory antifibrotic agent

Key facts

CAS number

53179-13-8

Purity

>99%

Form

Solid

form

Molecular weight

185.22 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>1</sub>NO

PubChem

40632

Nature

Synthetic

Solubility

Soluble in 1 eq. HCl to 100 mM

Soluble in water to 25 mM

Biochemical name

Pirfenidone

Biological description

Orally active anti-inflammatory, antifibrotic and antiproliferative agent. Blood-brain barrier permeable. Shown to modulate cytokines TGF-β and TNF-α.

Canonical smiles

CC1=CN(C(=O)C=C1)C2=CC=CC=C2

InChi

InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3

InChiKey

ISWRGOKTTBVCFA-UHFFFAOYSA-N

IUPAC Name

5-methyl-1-phenylpyridin-2-one

style
left-column

Complementary Products

Primary Antibodies

AB271042

Anti-IL-6R antibody [EPR24322-143]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Trial Size

Western blot - Anti-IL-6R antibody [EPR24322-143] (AB271042)

  • 5
  • 1
Assay Kits

AB239725

Protein Synthesis Assay Kit (Green)

Flow Cytometry - Protein Synthesis Assay Kit (Green) (AB239725)

  • 0
  • 0
Primary Antibodies

AB229050

Anti-XIAP antibody [EPR22189-113]

RabMAb|Recombinant|KO Validated

Western blot - Anti-XIAP antibody [EPR22189-113] (AB229050)

  • 0
  • 0
Primary Antibodies

AB220163

Anti-YTHDF2 antibody [EPR20318]

RabMAb|Recombinant|KO Validated

Western blot - Anti-YTHDF2 antibody [EPR20318] (AB220163)

  • 5
  • 3
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Veterinary ophthalmology 22:502-509 PubMed30701645

2019

Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Hans D Westermeyer,Beth Salmon,Ronald Baynes,James Yeatts,Ahlam Khattab,Annie Oh,Freya Mowat
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com