Piroxicam, cyclooxygenase-1 (COX-1) inhibitor
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MW 331.3 Da, Purity >99%. Reversible, selective cyclooxygenase-1 (COX-1) inhibitor. Shows 8-fold greater activity against COX-1 than COX-2 (IC50 values are 0.76 and 8.99 μM for COX-1 and COX-2, respectively).
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(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, AHR_HUMAN, Ah receptor, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, BAZ2B_HUMAN, Bromodomain adjacent to zinc finger domain 2B, Bromodomain adjacent to zinc finger domain protein 2B, CP2C9_HUMAN, CP2D6_HUMAN, CPC12, CPC8, CPC9, CPCJ, CPD6, CYP2C, CYP2C10, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIIC9, CYPIID6, Cholesterol 25-hydroxylase, Class E basic helix-loop-helix protein 76, Cyclooxygenase, Cyclooxygenase 2b, Cyclooxygenase 3, included, Cyclooxygenase-1, Cyclooxygenase-2, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-DB1, DKFZp434H071, DKFZp762I0516, Debrisoquine 4-hydroxylase, EC 1.14.99.1, FLJ45644, FLJ55736, GRIPGHS, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, Glucocorticoid-regulated inflammatory cyclooxygenase, HGNC:348, MGC149605, MGC45260, MGC88320, Macrophage activation-associated marker protein P71/73, Microsomal monooxygenase, OAT1, OTTHUMP00000020135, OTTHUMP00000033524, OTTHUMP00000162897, OTTHUMP00000162898, OTTHUMP00000236796, OTTHUMP00000236797, OTTHUMP00000236798, OTTHUMP00000236799, Organic anion transporter 1, Organic anion transporter 3, P450 DB1, P450 MP, P450 PB 1, P450C2C, P450C2D, P450IIC19, P450IIC9, PAH transporter, PAHT, PCOX1, PES-2, PGG/HS, PGH synthase 1, PGH synthase 2, PGH1_HUMAN, PGH2_HUMAN, PGHS-1, PGHS-2, PHS 1, PHS 2, PHS II, PTGHS, PTGS1, PTGS2, Para aminohippurate transporter, Partial COX1 proteins, included, Prostaglandin G/H synthase, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 1, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 2, ROAT1, Renal organic anion transporter 1, S-mephenytoin 4-hydroxylase, S22A6_HUMAN, S22A8_HUMAN, SLC22A8, Solute carrier family 22 (organic anion transporter) member 6, Solute carrier family 22 (organic anion transporter), member 8, Solute carrier family 22 member 6, Solute carrier family 22 member 8, TIS10, TIS10 protein, WALp4, Xenobiotic monooxygenase, bHLHe76, cytochrome P-450 S-mephenytoin 4-hydroxylase, fj02a10, flavoprotein-linked monooxygenase, hCox 2, hOAT1, hOAT3, hPAHT, hROAT1, hWALp4, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), ptgs2a, unp1239, wu:fj02a10
- Chemical Structure
Lab
Chemical Structure - Piroxicam, cyclooxygenase-1 (COX-1) inhibitor (AB141110)
2D chemical structure image of ab141110, Piroxicam, cyclooxygenase-1 (COX-1) inhibitor
Properties and storage information
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Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
COX1 and COX2 facilitate the production of signaling molecules in various physiological processes. They form a complex with other proteins as part of their enzymatic activity. For instance cytochrome P450 enzymes like CYP2D6 CYP2C9 and their relatives (Cytochrome P450 2C8 2C9 2C19 2C12) share a role in drug metabolism and detoxification. The aryl hydrocarbon receptor (AHR) also interacts with these enzymes influencing their expression under certain conditions. Notably these enzymes have distinct but sometimes overlapping functions that ensure regular metabolic and inflammatory responses.
Pathways
COX enzymes participate in the arachidonic acid metabolism pathway essential for producing prostaglandins and thromboxanes. This pathway also involves cytochrome P450 enzymes which contribute to the metabolism of lipids and xenobiotics. SLC22A6 known as OAT3 is involved in organic anion transport pathways that modulate drug excretion and disposition. These interconnected pathways establish a network through which cells maintain homeostasis and respond to environmental stimuli.
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