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AB120885

PIT-1, PIP3/protein binding inhibitor

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(1 Publication)

MW 351.76 g/mol, Purity >98%. PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.
1 Images
Chemical Structure - PIT-1, PIP3/protein binding inhibitor (AB120885)
  • Chemical Structure

Lab

Chemical Structure - PIT-1, PIP3/protein binding inhibitor (AB120885)

2D chemical structure image of ab120885, PIT-1, PIP3/protein binding inhibitor

Key facts

CAS number

53501-41-0

Purity

>98%

Form

Solid

form

Molecular weight

351.76 g/mol

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>0</sub>ClN<sub>3</sub>O<sub>4</sub>S

Nature

Synthetic

Solubility

Soluble in DMSO to 20 mg/ml

Soluble in ethanol to 0.5 mg/ml

Biological description

PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.

Canonical smiles

O=C(NC(NC1=C(O)C(CL)=CC([N+]([O-])=O)=C1)=S)C2=CC=CC=C2

IUPAC Name

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

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Complementary Products

Proteins & Peptides

AB171678

Recombinant Human PIP protein (denatured)

SDS-PAGE - Recombinant Human PIP protein (denatured) (AB171678)

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Biochemicals

AB144280

Ingenol-3-angelate, PKC activator

Chemical Structure - Ingenol-3-angelate, PKC activator (AB144280)

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Biochemicals

AB145221

L-alpha-Phosphatidylinositol-3,4,5-trisphosphate sodium salt, PKC delta, epsilon and eta activator

Chemical Structure - L-alpha-Phosphatidylinositol-3,4,5-trisphosphate sodium salt, PKC delta, epsilon and eta activator (AB145221)

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Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:4540 PubMed35927244

2022

Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Mostafa Bakhti,Aimée Bastidas-Ponce,Sophie Tritschler,Oliver Czarnecki,Marta Tarquis-Medina,Eva Nedvedova,Jessica Jaki,Stefanie J Willmann,Katharina Scheibner,Perla Cota,Ciro Salinno,Karsten Boldt,Nicola Horn,Marius Ueffing,Ingo Burtscher,Fabian J Theis,Ünal Coskun,Heiko Lickert
View all publications
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Product promise

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