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MW 404.4 Da. Novel, selective clathrin inhibitor. Competitively inhibits clathrin terminal domain (TD) to selectively inhibit clathrin mediated endocytosis (IC50 = ~18 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis, entry of HIV and synaptic vesicle recycling. Exhibits limited cell membrane penetration, however it is active in cells after microinjection.
- CAS number
1332879-51-2
- Form
Solid
- Molecular weight
404.4 Da
- Molecular formula
C19H13N2NaO5S
- PubChem identifier
71483522
- Nature
Synthetic
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MW 404.4 Da. Novel, selective clathrin inhibitor. Competitively inhibits clathrin terminal domain (TD) to selectively inhibit clathrin mediated endocytosis (IC50 = ~18 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis, entry of HIV and synaptic vesicle recycling. Exhibits limited cell membrane penetration, however it is active in cells after microinjection.
Key facts
- CAS number
1332879-51-2
- Form
Solid
- Molecular weight
404.4 Da
- Molecular formula
C19H13N2NaO5S
- PubChem identifier
71483522
- Nature
Synthetic
- Biochemical name
Pitstop 1
- Biological description
Novel, selective clathrin inhibitor. Competitively inhibits clathrin terminal domain (TD) to selectively inhibit clathrin mediated endocytosis (IC50 = ~18 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis, entry of HIV and synaptic vesicle recycling. Exhibits limited cell membrane penetration, however it is active in cells after microinjection.
- Canonical SMILES
C1=CC2=CC(=CC3=C2C(=C1)C(=O)N(C3=O)CC4=CC=C(C=C4)N)S(=O)(=O)[O-].[Na+]
- InChI
InChI=1S/C19H14N2O5S.Na/c20-13-6-4-11(5-7-13)10-21-18(22)15-3-1-2-12-8-14(27(24,25)26)9-16(17(12)15)19(21)23;/h1-9H,10,20H2,(H,24,25,26);/q;+1/p-1
- InChIKey
MKPPGLKJTZAXNE-UHFFFAOYSA-M
- IUPAC name
sodium;2-[(4-aminophenyl)methyl]-1,3-dioxobenzo[de]isoquinoline-5-sulfonate
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute.
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