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AB120688

Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop®2

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(18 Publications)

MW 409.3 g/mol, Purity >99%. Negative control for clathrin inhibitor Pitstop® 2 (ab120687) which is of the same chemical class and has a highly related structure to Pitstop® 2. Inhibits amphiphysin binding to the clathrin TD with an IC50 >100 μM and does not block receptor-mediated endocytosis at concentrations of up to 300 μM (unpublished reports).
1 Images
Chemical Structure - Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop®2 (AB120688)
  • Chemical Structure

Lab

Chemical Structure - Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop®2 (AB120688)

2D chemical structure image of ab120688, Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop®2

Key facts

CAS number

1576239-29-6

Purity

>99%

Form

Solid

form

Molecular weight

409.3 g/mol

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Negative control for clathrin inhibitor Pitstop® 2 (ab120687) which is of the same chemical class and has a highly related structure to Pitstop® 2. Inhibits amphiphysin binding to the clathrin TD with an IC50 >100 μM and does not block receptor-mediated endocytosis at concentrations of up to 300 μM (unpublished reports).

IUPAC Name

5-(4-Bromobenzylidene)-2-(naphthalen-1-ylamino)-1,3-thiazol-4(5H)-one

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Product details

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (18)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1012564 PubMed40067817

2025

The CLIC/GEEC pathway regulates particle uptake and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Kathleen Candor,Lingmei Ding,Sai Balchand,Jason E Hammonds,Paul Spearman

Cellular and molecular life sciences : CMLS 82:8 PubMed39694922

2024

Required minimal protein domain of flower for synaptobrevin2 endocytosis in cytotoxic T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Keerthana Ravichandran,Claudia Schirra,Katja Urbansky,Szu-Min Tu,Nadia Alawar,Stefanie Mannebach,Elmar Krause,David Stevens,C Roy D Lancaster,Veit Flockerzi,Jens Rettig,Hsin-Fang Chang,Ute Becherer

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2402317 PubMed39360573

2024

Membrane Tension Regulation is Required for Wound Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Nikita Raj,Martin S Weiß,Bart E Vos,Sarah Weischer,Frauke Brinkmann,Timo Betz,Britta Trappmann,Volker Gerke

Frontiers in cell and developmental biology 10:1075364 PubMed36605723

2022

Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification.

Applications

Unspecified application

Species

Unspecified reactive species

Reem Abu Rass,Japhette Esther Kembou-Ringert,Rachel Zamostiano,Avi Eldar,Marcelo Ehrlich,Eran Bacharach

Scientific reports 12:6264 PubMed35428843

2022

Sterolight as imaging tool to study sterol uptake, trafficking and efflux in living cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jarmila Králová,Martin Popr,Jan Valečka,Petr Bartůněk

Circulation research 124:52-65 PubMed30582444

2018

CLIC4/Arf6 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Vahitha B Abdul-Salam,Giusy Russomanno,Chen Chien-Nien,Abdul S Mahomed,Luke A Yates,Martin R Wilkins,Lan Zhao,Magdalena Gierula,Oliver Dubois,Ute Schaeper,Jens Endruschat,Beata Wojciak-Stothard

Molecular cell 70:106-119.e10 PubMed29625032

2018

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Martínez-Muñoz,José Miguel Rodríguez-Frade,Rubén Barroso,Carlos Óscar S Sorzano,Juan A Torreño-Pina,César A Santiago,Carlo Manzo,Pilar Lucas,Eva M García-Cuesta,Enric Gutierrez,Laura Barrio,Javier Vargas,Graciela Cascio,Yolanda R Carrasco,Francisco Sánchez-Madrid,María F García-Parajo,Mario Mellado

Journal of immunology (Baltimore, Md. : 1950) 197:2473-84 PubMed27527597

2016

Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Hsin-Fang Chang,Hawraa Bzeih,Claudia Schirra,Praneeth Chitirala,Mahantappa Halimani,Emmanuelle Cordat,Elmar Krause,Jens Rettig,Varsha Pattu

American journal of physiology. Renal physiology 311:F103-11 PubMed27076649

2016

Extracellular purines' action on glomerular albumin permeability in isolated rat glomeruli: insights into the pathogenesis of albuminuria.

Applications

Unspecified application

Species

Unspecified reactive species

Małgorzata Kasztan,Agnieszka Piwkowska,Ewelina Kreft,Dorota Rogacka,Irena Audzeyenka,Mirosława Szczepanska-Konkel,Maciej Jankowski

Traffic (Copenhagen, Denmark) 17:21-39 PubMed26459807

2015

HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Albecka,Romain F Laine,Anne F J Janssen,Clemens F Kaminski,Colin M Crump
View all publications
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