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AB120981

PJ34 hydrochloride, PARP-1 inhibitor

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(10 Publications )

MW 331.8 Da, Purity >98%. Potent, selective PARP-1 inhibitor (EC50 = 20 nM). Able to reduce both cell injury induced following deprivation of oxygen-glucose in vitro and infarct size following focal cerebral ischemia in vivo.
1 Images
Chemical Structure - PJ34 hydrochloride, PARP-1 inhibitor (AB120981)
  • Chemical Structure

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Chemical Structure - PJ34 hydrochloride, PARP-1 inhibitor (AB120981)

2D chemical structure image of ab120981, PJ34 hydrochloride, PARP-1 inhibitor

Key facts

CAS number

344458-15-7

Purity

>98%

Form

Solid

form

Molecular weight

331.8 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>8</sub>ClN<sub>3</sub>O<sub>2</sub>

PubChem

16760621

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

PJ34 hydrochloride

Biological description

Potent, selective PARP-1 inhibitor (EC50 = 20 nM). Able to reduce both cell injury induced following deprivation of oxygen-glucose in vitro and infarct size following focal cerebral ischemia in vivo.

Canonical smiles

CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl

InChi

InChI=1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H

InChiKey

RURAZZMDMNRXMI-UHFFFAOYSA-N

IUPAC Name

2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride

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Complementary Products

Primary Antibodies

AB288724

Anti-CD4 antibody [RM1013]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-CD4 antibody [RM1013] (AB288724)

  • 5
  • 4
Primary Antibodies

AB83306

Anti-SNRP70/U1-70K antibody

BOND RX™ Validated

Western blot - Anti-SNRP70/U1-70K antibody (AB83306)

  • 4
  • 1
Assay Kits

AB108791

Mouse Albumin ELISA Kit

Competitive ELISA - Mouse Albumin ELISA Kit (AB108791)

  • 0
  • 0
Proteins & Peptides

AB116200

Recombinant Human SNRPA1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human SNRPA1 protein (His tag N-Terminus) (AB116200)

  • 0
  • 0
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Rapid communications in mass spectrometry : RCM 39:e9961 PubMed39632390

2024

In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.

Applications

Unspecified application

Species

Unspecified reactive species

Taku Kasai,Yuto Nakamura,Masanori Aikawa,Sasha A Singh

The Journal of biological chemistry 300:107609 PubMed39074634

2024

Development and characterization of recombinant ADP-ribose binding reagents that allow simultaneous detection of mono and poly ADP-ribose.

Applications

Unspecified application

Species

Unspecified reactive species

Shu-Ping Chiu,Cristel V Camacho,W Lee Kraus

The FEBS journal 290:1596-1624 PubMed36239430

2022

Early loss of endogenous NAD following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Ankita Sarkar,Sourav Dutta,Malinki Sur,Semanti Chakraborty,Puja Dey,Piyali Mukherjee

Cardiovascular therapeutics 2022:8684014 PubMed35069800

2022

Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Liu,Quanli Pan

Nature communications 12:3931 PubMed34168143

2021

Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Rebecca Gupte,Tulip Nandu,W Lee Kraus

Frontiers in cell and developmental biology 8:590242 PubMed33282869

2020

Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mihaela Robu,Rashmi G Shah,Girish M Shah

Methods in molecular biology (Clifton, N.J.) 1813:77-90 PubMed30097862

2018

Assays for NAD-Dependent Reactions and NAD Metabolites.

Applications

Unspecified application

Species

Unspecified reactive species

Michael B Schultz,Yuancheng Lu,Nady Braidy,David A Sinclair

Nucleic acids research 45:11088-11105 PubMed28977633

2017

Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome.

Applications

Unspecified application

Species

Unspecified reactive species

Kyle A Nilson,Christine K Lawson,Nicholas J Mullen,Christopher B Ball,Benjamin M Spector,Jeffery L Meier,David H Price

Diabetes 65:2502-15 PubMed27284105

2016

NOV/CCN3: A New Adipocytokine Involved in Obesity-Associated Insulin Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Cécile Martinerie,Marie Garcia,Thi Thu Huong Do,Bénédicte Antoine,Marthe Moldes,Guillaume Dorothee,Chantal Kazazian,Martine Auclair,Marion Buyse,Tatiana Ledent,Pierre-Olivier Marchal,Maria Fesatidou,Adrien Beisseiche,Haruhiko Koseki,Shuichi Hiraoka,Christos Evangelos Chadjichristos,Bertrand Blondeau,Raphael Georges Denis,Serge Luquet,Bruno Fève

Journal of hematology & oncology 8:117 PubMed26497583

2015

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Tao Bai,Ramona Moles,Hassiba Chaib-Mezrag,Christophe Nicot
View all publications
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