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AB120559

PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors

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(1 Publication)

MW 311.72 Da, Purity >99%. Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
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Chemical Structure - PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (AB120559)
  • Chemical Structure

Lab

Chemical Structure - PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (AB120559)

2D chemical structure image of ab120559, PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors

Key facts

CAS number

501925-31-1

Purity

>99%

Form

Solid

form

Molecular weight

311.72 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>4</sub>ClN<sub>3</sub>O<sub>4</sub>

PubChem

311434

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea

Biological description

Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.

Canonical smiles

CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl

InChi

InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)

InChiKey

CEIIEALEIHQDBX-UHFFFAOYSA-N

IUPAC Name

1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea

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Biochemicals

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of stem cells 9:230-238 PubMed27572711

2016

The Effect of Thymoquinone, α7 Receptor Agonist and α7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation.

Applications

FuncS

Species

Unspecified reactive species

Lamiaa Ibrahim AbdEl Fattah,Maha Baligh Zickri,Lobna Abdel Aal,Ola Heikal,Esraa Osama
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