MW 301.2 Da, Purity >99%. Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT3 receptors (IC50 = 4541 nM).
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- Frontiers in immunology 13:8701742022Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Su,Wei Zhang,Ruoxi Zhang,Quan Yuan,Ruixia Wu,Xiaoxuan Liu,Jimusi Wuri,Ran Li,Tao YanPubMed 35812436
- Neuroscience letters 731:1351182020PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKe-Wei Chang et. al.PubMed 32502508
- Behavioural brain research 386:1125382020Dysfunction of inflammation-resolving pathways is associated with postoperative cognitive decline in elderly mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMoxuan Gong,Gongming Wang,Guodong Li,Jie Liu,Panpan Sun,Lichi Xu,Jingjing Li,Yanjing Guo,Mengyuan ZhangPubMed 32113876
- Neurochemistry international 120:238-2502018Activation of α7 nicotinic acetylcholine receptor alleviates Aβ-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKe-Wei Chang et. al.PubMed 30217465
- Journal of neurochemistry 145:68-792018Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFlavio H Beraldo et. al.PubMed 29265373
- International journal of stem cells 9:230-2382016The Effect of Thymoquinone, α7 Receptor Agonist and α7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation.Applications:FuncSReactive species:Unspecified reactive speciesLamiaa Ibrahim AbdEl Fattah,Maha Baligh Zickri,Lobna Abdel Aal,Ola Heikal,Esraa OsamaPubMed 27572711
Key facts
- CAS number
- 123464-89-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 301.2 Da
- Molecular formula
- C14H18Cl2N2O
- PubChem identifier
- 11243536
- Nature
- Synthetic
Target data
Recommended products
MW 301.2 Da, Purity >99%. Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT3 receptors (IC50 = 4541 nM).
Key facts
- CAS number
- 123464-89-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 301.2 Da
- Molecular formula
- C14H18Cl2N2O
- PubChem identifier
- 11243536
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)
- Biological description
Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT3 receptors (IC50 = 4541 nM).
- Canonical SMILES
- C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl.Cl
- Isomeric SMILES
- C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl.Cl
- InChI
- InChI=1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1
- InChIKey
- HSEQUIRZHDYOIX-ZOWNYOTGSA-N
- IUPAC name
- N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - PNU 282987, alpha7 nAChR agonist (ab120558)
2D chemical structure image of ab120558, PNU 282987, alpha7 nAChR agonist
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