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AB144613

PNU 74654, Wnt signaling pathway blocker

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(1 Publication)

MW 320.3 Da, Purity >98%. Wnt signaling pathway blocker. Inhibits Wnt/β-catenin pathway. Blocks the protein-protein interaction between β-catenin and TCF. Antitumor effects.
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Chemical Structure - PNU 74654, Wnt signaling pathway blocker (AB144613)
  • Chemical Structure

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Chemical Structure - PNU 74654, Wnt signaling pathway blocker (AB144613)

2D chemical structure image of ab144613, PNU 74654, Wnt signaling pathway blocker

Key facts

CAS number

113906-27-7

Purity

>98%

Form

Solid

form

Molecular weight

320.3 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>6</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

60119583

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

N-[(5-methyl-2-furanyl)methylideneamino]-2-phenoxybenzamide

Biological description

Wnt signaling pathway blocker. Inhibits Wnt/β-catenin pathway. Blocks the protein-protein interaction between β-catenin and TCF. Antitumor effects.

Canonical smiles

CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3

InChi

InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)

InChiKey

JJEDWBQZCRESJL-UHFFFAOYSA-N

IUPAC Name

N-[(5-methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular medicine (Berlin, Germany) 97:1169-1182 PubMed31187175

2019

Radiation-induced glucocorticoid receptor promotes CD44+ prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Chen,Xiaodong Chen,Yu Ren,Guobin Weng,Peter C Keng,Yuhchyau Chen,Soo Ok Lee
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