PP 1, Src family tyrosine kinase inhibitor

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MW 281.36 Da, Purity >98%. Potent Src family tyrosine kinase inhibitor. Inhibits a multitude of kinases (IC₅₀ values are 0.05 (LCK), 0.52 (CSK), 0.64 (p38α) and 1.06 (CK1δ) μM). Inhibits Bcr-Abl kinase and induces apoptosis.

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ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1_HUMAN, AI838772, ASV, AW259666, AW493413, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Angiopoietin-1 receptor, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Avian sarcoma virus, Bcr/c abl oncogene protein, C SRC, C ret, C syn protooncogene, C-SRC kinase, C-kit ligand, CARD 3, CARD carrying kinase, CARD containing ICE associated kinase, CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase, CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARDIAK, CD 140B, CD117, CD140A, CD140a antigen, CD140b antigen, CD202b, CD202b antigen, CD309, CD309 antigen, CDHF 12, CDHR16, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CKI-delta, CKId, CLARP kinase, CSAID Binding Protein 1, CSAID-binding protein, CSBP, CSBP 1, CSBP 2, CSK_HUMAN, CSNK 1D, CSPB1, CYTOPLASMIC TYROSINE KINASE, Cadherin family member 12, Cadherin related family member 16, Casein Kinase 1 delta, Casein kinase I delta isoform, Casein kinase I isoform delta, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, Cellular Yes 1 protein, Csaids binding protein, Csk A, Cytokine suppressive anti-inflammatory drug-binding protein, EC 2.7.10.1, EC 2.7.10.2, EGFR_HUMAN, ELKS Fusion gene, ERBB, ERBB1, EXIP, Endothelial tyrosine kinase, Endothelium specific receptor tyrosine kinase 2, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Errp, FK506 binding protein 12 rapamycin associated protein 1, FK506 binding protein 12 rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, FLJ11090, FLJ44809, FLK-1, FLK1, mouse, homolog of, FRAP, FRAP1, FRAP2, FYN oncogene related to SRC FGR YES, FYN_HUMAN, Fetal liver kinase 1, GIG 30, Growth inhibiting gene 30, HCKID, HER1, HSCR 1, HsT441, Hyk, IMD22, JTK7, KC1D_HUMAN, KIT ligand, KIT oncogene, KIT proto oncogene receptor tyrosine kinase, KIT_HUMAN, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LSK, Lck p56, Leukocyte C-terminal Src kinase, Ly73, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAX-interacting protein 2, MEN2A, MEN2B, MGC104252, MGC112732, MGC112926, MGC117393, MGC154049, MGF, MK14_HUMAN, MTC 1, MTOR_HUMAN, Mammalian target of rapamycin, Mast cell growth factor receptor, Mast/stem cell growth factor receptor Kit, Mechanistic target of rapamycin, Membrane associated protein tyrosine kinase, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Mxi 2, NISBD2, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OKT3 induced calcium influx regulator, OTTHUMP00000001983, OTTHUMP00000174476, OTTHUMP00000174477, Oncogen ERBB, Oncogene RET, Oncogene SRC, Oncogene lck, P150, P38, PBT, PDGF Receptor alpha + beta, PDGF-R-alpha, PDGF-R-beta, PDGFR 2, PDGFRA, PDGFRB, PIG61, PRKM14, PRKM15, PTC, Piebald trait protein, Platelet derived growth factor receptor alpha, Platelet derived growth factor receptor beta, Protein YT16, Protein kinase CK1 delta, Protein tyrosine kinase fyn, Protein-tyrosine kinase CYL, Protein-tyrosine kinase receptor flk-1, Proto oncogene tyrosine protein kinase, Proto oncogene tyrosine protein kinase ABL1, Proto oncogene tyrosine protein kinase Kit, Proto oncogene tyrosine protein kinase LCK, Proto oncogene tyrosine protein kinase YES, Proto oncogene tyrosine protein kinase fyn, Proto-oncogene Lck, Proto-oncogene Syn, Proto-oncogene c-Abl, Proto-oncogene c-ErbB-1, Proto-oncogene c-Fyn, Proto-oncogene c-Kit, Proto-oncogene c-Ret, Proto-oncogene c-Src, Proto-oncogene c-Yes, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor ret, Protooncogene SRC, Protooncogene SRC Rous sarcoma, RAFT1, RAPT1, RET ELE1, RET transforming sequence, RET51, RET9, RET_HUMAN, RICK, RIP-like-interacting CLARP kinase, RIPK2_HUMAN, RK, RP24-311F12.2, Rapamycin and FKBP12 target 1, Rapamycin associated protein FRAP2, Rapamycin target protein, Rapamycin target protein 1, Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase, Receptor interacting serine threonine kinase 2, Receptor tyrosine-protein kinase ErbB-1, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, Ret Proto oncogene, SA7, SAPK2A, SCAN1, SCF Receptor, SCFR, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, SYN, Serine/threonine-protein kinase mTOR, Soluble TIE2 variant 1, Soluble TIE2 variant 2, Species antigen 7, Src yes related novel gene, Src-like kinase, Src/yes related novel, Steel Factor Receptor, Stem cell factor receptor, Stress-activated protein kinase 2a, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, TEK tyrosine kinase endothelial, TIE2_HUMAN, TNFRSF, TYDP, TYDP1_HUMAN, Tek, Tunica interna endothelial cell kinase, Tyr-DNA phosphodiesterase 1, Tyrosine kinase growth factor receptor, Tyrosine kinase p59fyn T, Tyrosine kinase p59fyn(T), Tyrosine kinase pp60c src, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine protein kinase SRC 1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase Kit, Tyrosine-protein kinase Lck, Tyrosine-protein kinase RIPK2, Tyrosine-protein kinase Yes, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, Tyrosyl-DNA phosphodiesterase 1, UNQ277/PRO314/PRO34092, Urogastrone, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), VEGFR, VEGFR-2, VGFR2_HUMAN, VMCM, VMCM 1, Vascular endothelial growth factor receptor 2, Venous malformations multiple cutaneous and mucosal, Viral oncogene yes 1 homolog 1, Wa5, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, YT 16, Yamaguchi sarcoma oncogene, Yes 1, bcr/abl, c ABL, c Yes, c abl oncogene 1 non receptor tyrosine kinase, c abl oncogene 1 receptor tyrosine kinase, c-Kit, c-src tyrosine kinase, dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1), erb-b2 receptor tyrosine kinase 1, hTIE 2, hydroxyaryl-protein kinase, mENA, p140 TEK, p145 c-kit, p38 ALPHA, p38 MAP kinase, p38 MAPK, p38 mitogen activated protein kinase, p38alpha Exip, p56(LSTRA) protein tyrosine kinase, p56-LCK, p59-Fyn, p60-Src, p60c-src, p61-Yes, pp58 lck, pp60c-src, soluble KIT variant 1, soluble VEGFR2, tek tyrosine kinase, tyrosine-protein kinase receptor ret, v abl, v abl Abelson murine leukemia viral oncogene homolog 1, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, wa2, zgc:154049