PP2, Src and RIP2 kinase inhibitor
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(17 Publications)
MW 301.77 Da, Purity >98%. Inhibitor of the Src family of kinases. Inhibits Src and Lck kinase (IC50 values are 36 and 31 nM, respectively). Also shown to inhibit RIP2 and CK1δ (IC50 values are 19 and 41 nM, respectively).
View Alternative Names
ASV, AW259666, Avian sarcoma virus, C SRC, CARD 3, CARD carrying kinase, CARD containing ICE associated kinase, CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase, CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARDIAK, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CLARP kinase, EC 2.7.10.2, GIG 30, Growth inhibiting gene 30, IMD22, LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LSK, Lck p56, Leukocyte C-terminal Src kinase, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, Membrane associated protein tyrosine kinase, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OTTHUMP00000174476, OTTHUMP00000174477, Oncogene SRC, Oncogene lck, Protein YT16, Proto oncogene tyrosine protein kinase LCK, Proto-oncogene Lck, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, Protooncogene SRC Rous sarcoma, RICK, RIP-like-interacting CLARP kinase, RIPK2_HUMAN, Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase, Receptor interacting serine threonine kinase 2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, TNFRSF, Tyrosine kinase pp60c src, Tyrosine protein kinase SRC 1, Tyrosine-protein kinase Lck, Tyrosine-protein kinase RIPK2, UNQ277/PRO314/PRO34092, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), YT 16, p56(LSTRA) protein tyrosine kinase, p56-LCK, p60-Src, p60c-src, pp58 lck, pp60c-src, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian
- FuncS
Unknown
Functional Studies - PP2, Src and RIP2 kinase inhibitor (AB120308)
ab11512 staining E-Cadherin in SW480 cells treated with PP2 (ab120308), by ICC/IF. Increase in E-cadherin expression correlates with increased concentration of PP2, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120308 (PP2) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab11512 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rat polyclonal antibody (ab96971) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
- Chemical Structure
Lab
Chemical Structure - PP2, Src and RIP2 kinase inhibitor (AB120308)
2D chemical structure image of ab120308, PP2, Src and RIP2 kinase inhibitor
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Src RIP2 and Lck contribute to signal transduction processes critical for cellular functions. Src commonly integrates into multi-protein complexes modulating pathways linked to cell cycle progression and proliferation. RIP2 is essential for activating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways important in inflammation and immune responses. Lck plays a pivotal role in T cell receptor (TCR) signaling initiating adaptive immune responses. These kinases often work together with other signaling proteins to ensure proper cellular outcomes in health and disease.
Pathways
Src RIP2 and Lck serve key roles in the regulation of two significant biological pathways: the NF-κB pathway and TCR signaling. Src kinase's activity modulates the activation of downstream proteins like STAT3 and FAK which influence cell adhesion and migration. RIP2 interacts with proteins such as NOD2 during innate immune responses facilitating the activation of NF-κB pathway. Lck functions upstream in TCR signaling where it is essential for phosphorylating ZAP-70 a step important for triggering downstream signaling cascades critical for T cell activation.
Publications (17)
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JCI insight 10: PubMed40493407
2025
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Glia 72:916-937 PubMed38372375
2024
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Proceedings of the National Academy of Sciences of the United States of America 120:e2316456120 PubMed38055737
2023
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Mediators of inflammation 2021:6639252 PubMed33927570
2021
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Cell reports 33:108245 PubMed33086058
2020
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Cell reports 29:4144-4158.e7 PubMed31851939
2019
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FASEB journal : official publication of the Federa 33:12812-12824 PubMed31469589
2019
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eLife 8: PubMed30947808
2019
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Biomaterials 161:164-178 PubMed29421553
2018
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eLife 6: PubMed29271742
2017
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