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MW 308.34 Da, Purity >98%. Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.

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Images

Chemical Structure - PP242, mTOR inhibitor (AB141405), expandable thumbnail

Publications

Key facts

Purity
> 98%
Molecular weight
308.34 Da
Molecular formula
C16H16N6O
PubChem identifier
25243800
Nature
Synthetic

Target data

Recommended products

MW 308.34 Da, Purity >98%. Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.

Key facts

Purity
> 98%
PubChem identifier
25243800
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
CID 25243800
Biological description

Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.

Canonical SMILES
CC(C)N1C2=NC=NC(=C2C(=C3C=C4C=C(C=CC4=N3)O)N1)N
Isomeric SMILES
CC(C)N1C2=NC=NC(=C2/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)N
InChI
InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+
InChIKey
MTICIDWIKCANDD-WYMLVPIESA-N
IUPAC name
(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1658 PP242. 1658-1 is the same size as the 1 mg size of ab141405.

Product promise

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1 product image

  • Chemical Structure - PP242, mTOR inhibitor (ab141405), expandable thumbnail

    Chemical Structure - PP242, mTOR inhibitor (ab141405)

    2D chemical structure image of ab141405, PP242, mTOR inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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