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AB141405

PP242, mTOR inhibitor

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(1 Publication)

MW 308.34 Da, Purity >98%. Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.
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Chemical Structure - PP242, mTOR inhibitor (AB141405)
  • Chemical Structure

Lab

Chemical Structure - PP242, mTOR inhibitor (AB141405)

2D chemical structure image of ab141405, PP242, mTOR inhibitor

Key facts

Purity

>98%

Molecular weight

308.34 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>6</sub>N<sub>6</sub>O

PubChem

25243800

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

CID 25243800

Biological description

Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.

Canonical smiles

CC(C)N1C2=NC=NC(=C2C(=C3C=C4C=C(C=CC4=N3)O)N1)N

Isomeric smiles

CC(C)N1C2=NC=NC(=C2/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)N

InChi

InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+

InChiKey

MTICIDWIKCANDD-WYMLVPIESA-N

IUPAC Name

(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1658 PP242. 1658-1 is the same size as the 1 mg size of ab141405.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Developmental cell 45:580-594.e7 PubMed29804876

2018

Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.

Applications

Unspecified application

Species

Unspecified reactive species

Yan M Zhang,Milena A Zimmer,Talia Guardia,Scott J Callahan,Chandrani Mondal,Julie Di Martino,Toshimitsu Takagi,Myles Fennell,Ralph Garippa,Nathaniel R Campbell,Jose Javier Bravo-Cordero,Richard M White
View all publications
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