MW 599.3 Da. PPADS, P2 purinergic receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
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- Biophysics and physicobiology 19:e1900412022Influence of gap junctions upon Ca propagation from stimulated keratinocytes to DRG neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChiaki Seto,Kenta Toyoda,Kousuke Inada,Kotaro Oka,Etsuro ItoPubMed 36349331
- Scientific reports 11:151292021Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSai Krishna Srimadh Bhagavatham,Prakash Khanchandani,Vishnu Kannan,Damodaram Potikuri,Divya Sridharan,Sujith Kumar Pulukool,Ashwin Ashok Naik,Rajesh Babu Dandamudi,Sai Mangala Divi,Ashish Pargaonkar,Rahul Ray,Saibharath Simha Reddy Santha,Polani B Seshagiri,K Narasimhan,Narsimulu Gumdal,Venketesh SivaramakrishnanPubMed 34301999
- Scientific reports 11:97662021Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSujith Kumar Pulukool,Sai Krishna Srimadh Bhagavatham,Vishnu Kannan,Piruthivi Sukumar,Rajesh Babu Dandamudi,Shamika Ghaisas,Haripriya Kunchala,Darshan Saieesh,Ashwin Ashok Naik,Ashish Pargaonkar,Anuj Sharma,Venketesh SivaramakrishnanPubMed 33963197
- Glia 67:78-902018Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWen-Feng Su,Fan Wu,Zi-Han Jin,Yun Gu,Ying-Ting Chen,Ying Fei,Hui Chen,Ya-Xian Wang,Ling-Yan Xing,Ya-Yu Zhao,Ying Yuan,Xin Tang,Gang ChenPubMed 30306657
- PloS one 13:e01908932018Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBoriana K Tchernookova et. al.PubMed 29466379
- Scientific reports 5:168952015Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSu-Jin Heo et. al.PubMed 26592929
- Journal of neurophysiology 114:159-692015ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHildebrando Candido Ferreira-Neto,Vagner R Antunes,Javier E SternPubMed 25904713
- British journal of pharmacology 162:974-882010Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFlora E Kovacs,Peter Illes,Bela SzaboPubMed 21054344
- PLoS biology 8:e10003522010An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarta Gómez-Gonzalo et. al.PubMed 20405049
- The Journal of general physiology 135:333-532010P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEstelle Toulme et. al.PubMed 20231374
Key facts
- CAS number
192575-19-2
- Form
Solid
- Molecular weight
599.3 Da
- Molecular formula
C14H10N3Na4O12PS2
- Nature
Synthetic
Recommended products
MW 599.3 Da. PPADS, P2 purinergic receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
192575-19-2
- Form
Solid
- Molecular weight
599.3 Da
- Molecular formula
C14H10N3Na4O12PS2
- Nature
Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
Ppads tetrasodium salt
- Canonical SMILES
CC1=C(C(=C(C(=N1)N=NC2=C(C=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])COP(=O)([O-])[O-])C=O)O.[Na+].[Na+].[Na+].[Na+]
- IUPAC name
tetrasodium;4-[[4-formyl-5-hydroxy-6-methyl-3-(phosphonatooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonate
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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4 product images
Chemical Structure - PPADS, P2 purinergic receptor antagonist (ab120009)
2D chemical structure image of ab120009, PPADS, P2 purinergic receptor antagonist
Image from Tchernookova B, et al. Plos One, 13(2), e0190893. Fig 2c,; doi: 10.1371/journal.pone.0190893Cellular Activation - PPADS, P2 purinergic receptor antagonist (ab120009)
Inhibition by suramin and PPADS significantly reduces the ATP-induced increase in extracellular H+ flux from isolated Müller cells.
Mean responses to 10 μM ATP with or without suramin and PPADS in the bath; N = 7, error bars represent SEMs.
Image from Gómez-Gonzalo M et al., PLoS Biol. 2010;8(4):e1000352. Fig 2.; doi: 10.1371/journal.pbio.1000352. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - PPADS, P2 purinergic receptor antagonist (ab120009)
Astrocyte Ca2+ signal inhibition does not affect interictal discharges.
(A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (MPEP hydrochloride, mGlu5 antagonist ab120008) (n=7), PPADS (ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.
Image from Gómez-Gonzalo M et al., PLoS Biol. 2010;8(4):e1000352. Fig 6(A).; doi: 10.1371/journal.pbio.1000352.Functional Studies - PPADS, P2 purinergic receptor antagonist (ab120009)
Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (MPEP hydrochloride, mGlu5 antagonist ab120008) and PPADS (ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.
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