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AB141077

PQ 401, Cell-permeable IGF1R inhibitor

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MW 341.8 Da, Purity >99%. Cell-permeable IGF1R inhibitor (IC50 = 12 μM for IGF-stimulated autophosphorylation). Shows antiproliferative effects against MCF-7 breast cancer cells. Induces renal hypertrophy in vivo. .

View Alternative Names

CD221, CD221 antigen, IGF 1 receptor, IGF-I receptor, IGF1R_HUMAN, IGFIR, IGFIRC, IGFR, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor precursor, Insulin-like growth factor 1 receptor beta chain, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, Soluble IGF1R variant 1, Soluble IGF1R variant 2

1 Images
Chemical Structure - PQ 401, Cell-permeable IGF1R inhibitor (AB141077)
  • Chemical Structure

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Chemical Structure - PQ 401, Cell-permeable IGF1R inhibitor (AB141077)

2D chemical structure image of ab141077, PQ 401, Cell-permeable IGF1R inhibitor

Key facts

CAS number

196868-63-0

Purity

>99%

Form

Solid

form

Molecular weight

341.8 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>6</sub>ClN<sub>3</sub>O<sub>2</sub>

PubChem

9549305

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 10 mM

Biochemical name

1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea

Biological description

Cell-permeable IGF1R inhibitor (IC50 = 12 μM for IGF-stimulated autophosphorylation). Shows antiproliferative effects against MCF-7 breast cancer cells. Induces renal hypertrophy in vivo.

Canonical smiles

CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC

InChi

InChI=1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)

InChiKey

YBLWOZUPHDKFOT-UHFFFAOYSA-N

IUPAC Name

1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IGF1 Receptor often referred to as IGF-1R is a transmembrane receptor protein composed of alpha and beta subunits. Studies indicate that the IGF1R protein is involved in mediating the effects of insulin-like growth factor 1 (IGF-1) and plays an important role in cellular signaling. It has a molecular weight of approximately 180 kDa and is widely expressed in various tissues with high concentrations in the liver muscle and brain. Being a tyrosine kinase receptor IGF1R plays an essential role in growth and metabolism.
Biological function summary

IGF1R contributes to several cellular processes including cell proliferation differentiation and survival. This receptor forms a complex upon ligand binding and undergoes autophosphorylation to activate intracellular signaling cascades. IGF1R activation recruits and phosphorylates insulin receptor substrates enabling the downstream signaling pathways that promote cell growth and survival. Its function in cellular responses makes it a focal point in understanding cell biology.

Pathways

IGF1R holds a central position in the PI3K/AKT and MAPK signaling cascades. These pathways play significant roles in cellular growth proliferation and survival. IGF1R phosphorylates various downstream effectors such as IRS-1 and Shc linking it to the activation of AKT and ERK respectively. Therefore it shares pathways with related proteins like the insulin receptor highlighting its importance in mediating similar biological responses.

IGF1R has been implicated in cancers and diabetes. Overexpression of IGF1R has been observed in various malignancies including breast cancer where it relates to resistance in treatment and poor prognosis with cell lines like MCF-7 often being studied in this context. Additionally disruptions in IGF1R signaling link to insulin resistance an important feature of type 2 diabetes. These connections make IGF1R a potential therapeutic target with IGF1R inhibitors currently under exploration to address these health challenges.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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