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AB145974

PRIMA-1MET, p53 activity

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(1 Publication)

MW 199.25 Da, Purity >98%. Methylated derivative of PRIMA-1 (ab141641). Restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. Inhibits thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
1 Images
Chemical Structure - PRIMA-1MET, p53 activity (AB145974)
  • Chemical Structure

Lab

Chemical Structure - PRIMA-1MET, p53 activity (AB145974)

2D chemical structure image of ab145974, PRIMA-1MET, p53 activity

Key facts

CAS number

5291-32-7

Purity

>98%

Form

Solid

form

Molecular weight

199.25 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>1</sub><sub>7</sub>NO<sub>3</sub>

PubChem

52918385

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Apr-246

Biological description

Methylated derivative of PRIMA-1 (ab141641). Restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. Inhibits thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.

Canonical smiles

COCC1(C(=O)C2CCN1CC2)CO

InChi

InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3

InChiKey

BGBNULCRKBVAKL-UHFFFAOYSA-N

IUPAC Name

2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40565026

2025

Targeting the p53/xCT/GSH Axis with PRIMA-1 Combined with Sulfasalazine Shows Therapeutic Potential in Chronic Lymphocytic Leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Pasino,Andrea Speciale,Silvia Ravera,Giovanna Cutrona,Rosanna Massara,Nadia Bertola,Maurizio Viale,Irena Velkova,Andrea Nicola Mazzarello,Franco Fais,Fabrizio Loiacono,Serena Matis,Giulia Elda Valenti,Nicola Traverso,Cinzia Domenicotti,Barbara Marengo,Bruno Tasso,Adalberto Ibatici,Emanuele Angelucci,Tiziana Vaisitti,Paola Monti,Paola Menichini
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