PRL-3 Inhibitor I

Key facts

Purity

98%

Form

Solid

form

Molecular weight

485.2 Da

Molecular formula

C₁₇H₁₁Br₂NO₂S₂

PubChem

73707371

Nature

Synthetic

Solubility

Soluble in DMSO (up to 40 mg/ml)

Biochemical name

5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone

Biological description

A potent inhibitor of PRL-3, IC₅₀=0.9 μM. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells. Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.

Canonical smiles

C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)C=C3C(=O)NC(=S)S3)Br

Isomeric smiles

C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)/C=C/3\C(=O)NC(=S)S3)Br

InChi

InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+

InChiKey

HXNBAOLVPAWYLT-OVCLIPMQSA-N

IUPAC Name

(5E)-5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one