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AB120476

Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™

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MW 299.5 Da. Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an *in vitro* inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 μM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.
1 Images
Chemical Structure - Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ (AB120476)
  • Chemical Structure

Lab

Chemical Structure - Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ (AB120476)

2D chemical structure image of ab120476, Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™

Key facts

CAS number

43016-78-0

Form

Liquid

form

Molecular weight

299.5 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>3</sub><sub>7</sub>NO<sub>2</sub>

PubChem

96645

Nature

Synthetic

Biochemical name

2-(Dimethylamino)ethyl myristate

Biological description

Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an *in vitro* inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 μM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.

Canonical smiles

CCCCCCCCCCCCCC(=O)OCCN(C)C

InChi

InChI=1S/C18H37NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-18(20)21-17-16-19(2)3/h4-17H2,1-3H3

InChiKey

WVTLMDGNANZSAT-UHFFFAOYSA-N

IUPAC Name

2-(dimethylamino)ethyl tetradecanoate

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Product details

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Complementary Products

Biochemicals

AB120464

Dynole® 31-2, Negative control for Dynolereg 34-2

Immunocytochemistry/ Immunofluorescence - Dynole® 31-2, Negative control for Dynolereg 34-2 (AB120464)

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Biochemicals

AB120466

MiTMAB™, dynamin I and dynamin II inhibitor

Immunocytochemistry/ Immunofluorescence - MiTMAB™, dynamin I and dynamin II inhibitor (AB120466)

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Multiplex Kits

AB120468

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Biochemicals

AB120463

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