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AB120955

Procainamide hydrochloride, Sodium channel blocker

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(6 Publications)

MW 271.79 g/mol, Purity >99%. Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
1 Images
Chemical Structure - Procainamide hydrochloride, Sodium channel blocker (AB120955)
  • Chemical Structure

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Chemical Structure - Procainamide hydrochloride, Sodium channel blocker (AB120955)

2D chemical structure image of ab120955, Procainamide hydrochloride, Sodium channel blocker

Key facts

CAS number

614-39-1

Purity

>99%

Form

Solid

form

Molecular weight

271.79 g/mol

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>2</sub><sub>1</sub>N<sub>3</sub>O.HCl

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in ethanol to 100 mM

Biological description

Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.

IUPAC Name

4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cell reports. Medicine 4:101003 PubMed37044090

2023

Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.

Applications

Unspecified application

Species

Unspecified reactive species

Tom G Caniels,Max Medina-Ramírez,Jinsong Zhang,Anita Sarkar,Sonu Kumar,Alex LaBranche,Ronald Derking,Joel D Allen,Jonne L Snitselaar,Joan Capella-Pujol,Iván Del Moral Sánchez,Anila Yasmeen,Marilyn Diaz,Yoann Aldon,Tom P L Bijl,Sravani Venkatayogi,Joshua S Martin Beem,Amanda Newman,Chuancang Jiang,Wen-Hsin Lee,Maarten Pater,Judith A Burger,Mariëlle J van Breemen,Steven W de Taeye,Kimmo Rantalainen,Celia LaBranche,Kevin O Saunders,David Montefiori,Gabriel Ozorowski,Andrew B Ward,Max Crispin,John P Moore,Per Johan Klasse,Barton F Haynes,Ian A Wilson,Kevin Wiehe,Laurent Verkoczy,Rogier W Sanders

Immunity 55:2149-2167.e9 PubMed36179689

2022

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.

Applications

Unspecified application

Species

Unspecified reactive species

Jordan R Willis,Zachary T Berndsen,Krystal M Ma,Jon M Steichen,Torben Schiffner,Elise Landais,Alessia Liguori,Oleksandr Kalyuzhniy,Joel D Allen,Sabyasachi Baboo,Oluwarotimi Omorodion,Jolene K Diedrich,Xiaozhen Hu,Erik Georgeson,Nicole Phelps,Saman Eskandarzadeh,Bettina Groschel,Michael Kubitz,Yumiko Adachi,Tina-Marie Mullin,Nushin B Alavi,Samantha Falcone,Sunny Himansu,Andrea Carfi,Ian A Wilson,John R Yates,James C Paulson,Max Crispin,Andrew B Ward,William R Schief

Cell reports 35:108933 PubMed33826885

2021

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.

Applications

Unspecified application

Species

Unspecified reactive species

Ronald Derking,Joel D Allen,Christopher A Cottrell,Kwinten Sliepen,Gemma E Seabright,Wen-Hsin Lee,Yoann Aldon,Kimmo Rantalainen,Aleksandar Antanasijevic,Jeffrey Copps,Anila Yasmeen,Albert Cupo,Victor M Cruz Portillo,Meliawati Poniman,Niki Bol,Patricia van der Woude,Steven W de Taeye,Tom L G M van den Kerkhof,P J Klasse,Gabriel Ozorowski,Marit J van Gils,John P Moore,Andrew B Ward,Max Crispin,Rogier W Sanders

Structure (London, England : 1993) 28:897-909.e6 PubMed32433992

2020

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.

Applications

Unspecified application

Species

Unspecified reactive species

Gemma E Seabright,Christopher A Cottrell,Marit J van Gils,Alessio D'addabbo,David J Harvey,Anna-Janina Behrens,Joel D Allen,Yasunori Watanabe,Nicole Scaringi,Thomas M Polveroni,Allison Maker,Snezana Vasiljevic,Natalia de Val,Rogier W Sanders,Andrew B Ward,Max Crispin

Cell reports 25:3136-3147.e5 PubMed30540945

2018

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.

Applications

Unspecified application

Species

Unspecified reactive species

S Saif Hasan,Chengqun Sun,Arthur S Kim,Yasunori Watanabe,Chun-Liang Chen,Thomas Klose,Geeta Buda,Max Crispin,Michael S Diamond,William B Klimstra,Michael G Rossmann

Cell reports 24:1958-1966.e5 PubMed30134158

2018

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Applications

Unspecified application

Species

Unspecified reactive species

Weston B Struwe,Elena Chertova,Joel D Allen,Gemma E Seabright,Yasunori Watanabe,David J Harvey,Max Medina-Ramirez,James D Roser,Rodman Smith,David Westcott,Brandon F Keele,Julian W Bess,Rogier W Sanders,Jeffrey D Lifson,John P Moore,Max Crispin
View all publications

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