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AB141252

Progesterone, Endogenous progesterone receptor agonist

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MW 314.5 Da, Purity >99%. Endogenous progesterone receptor agonist (EC50 = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.
2 Images
Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)

ab16895 staining MDM2 in MCF7 cells treated with progesterone (ab141252), by ICC/IF. Decrease in MDM2 expression correlates with increased concentration of progesterone, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab141252 (progesterone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16895 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)
  • Chemical Structure

Lab

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)

2D chemical structure image of ab141252, Progesterone, Endogenous progesterone receptor agonist

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

314.5 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>2</sub>

PubChem

12303971

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

17-Acetylandrosta-4-ene-3-one

Biological description

Endogenous progesterone receptor agonist (EC50 = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.

Canonical smiles

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric smiles

CC(=O)C1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

InChi

InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17?,18-,19-,20-,21+/m0/s1

InChiKey

RJKFOVLPORLFTN-MWXAKFKLSA-N

IUPAC Name

(8S,9S,10R,13S,14S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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