MW 352.5 Da, Purity >99%. Potent EP1, EP2, EP3, and EP4 ligand (Kd values are 1 - 10 nM). COX product of arachidonic acid (ab120916). Shows potent vasodilatory and pro-nociceptive effects *in vivo.* 3D Growth matrix component used in liver and prostate organoid generation.
363-24-6
> 99%
Solid
352.5 Da
C20H32O5
5280360
Synthetic
ACLS, AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), CHNG1, DHTR, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), EP 3, EP 4, EP1, EP2, EP3 I, EP3 II, EP3 III, EP3 IV, EP3 subtype, EP3e, EP4R, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Ep3 prostanoid receptor, Ep3 receptor, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FLJ55736, FP, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HGNC:9595, HUMARA, HYSP1, IP, KD, Kennedy disease (KD), LGR 3, MGC120498, MGC126583, MGC141828, MGC141829, MGC27302, MGC34282, MGC45260, MGC46203, MGC75129, NLT, NR3B1, NR3C4, Novel liver transporter, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), OAT1, OAT2, OAT4, OTTHUMP00000236796, OTTHUMP00000236797, OTTHUMP00000236798, OTTHUMP00000236799, Oct-01, Oncogene GLI3, Organic anion transporter 1, Organic anion transporter 2, Organic anion transporter 3, Organic anion transporter 4, Organic anion transporter member 7, Organic anion transporter member 7 Fragment, Organic cation transporter 1, PAH transporter, PAHT, PAP A, PAPB, PE2R2_HUMAN, PE2R3_HUMAN, PE2R4_HUMAN, PF2R_HUMAN, PGE receptor EP1 subtype, PGE receptor EP2 subtype, PGE receptor EP3 subtype, PGE receptor EP4 subtype, PGE2 receptor EP1 subtype, PGE2 receptor EP2 subtype, PGE2 receptor EP3 subtype, PGE2 receptor EP4 subtype, PGE2-R, PGF receptor, PGF2-alpha receptor, PGI receptor, PGI2 receptor, PI2R_HUMAN, PPD IV, PRIPR, PTGER 2, PTGER 4, PTGER1, PTGFR, Para aminohippurate transporter, Pgerep3, Prostacyclin receptor, Prostaglandin E receptor 1 subtype EP1, Prostaglandin E receptor 1 subtype EP1 42kDa, Prostaglandin E receptor 2 EP2 subtype, Prostaglandin E receptor 2 subtype EP2, Prostaglandin E receptor 2 subtype EP2 53kDa, Prostaglandin E receptor 3, Prostaglandin E receptor 3 (subtype EP3), Prostaglandin E receptor 4, Prostaglandin E receptor 4 subtype EP4, Prostaglandin E receptor EP3 subtype 3 isoform, Prostaglandin E2 receptor, Prostaglandin E2 receptor EP1 subtype, Prostaglandin E2 receptor EP2 subtype, Prostaglandin E2 receptor EP3 subtype, Prostaglandin E2 receptor EP4 subtype, Prostaglandin F receptor, Prostaglandin F2-alpha receptor, Prostaglandin I2 (prostacyclin) receptor (IP), Prostaglandin I2 receptor, Prostaglandin e2 receptor ep3, Prostaglandin receptor (PGE 2), Prostaglandin receptor 2 alpha, Prostaglandin receptor 3, EP3, subtype, Prostanoid EP1 receptor, Prostanoid EP2 receptor, Prostanoid EP3 receptor, Prostanoid EP4 receptor, Prostanoid FP receptor, Prostanoid IP receptor, Ptgerep3, Ptgir, ROAT1, Renal organic anion transporter 1, Rep3, S22A1_HUMAN, S22A6_HUMAN, S22A7_HUMAN, S22A8_HUMAN, S22AB_HUMAN, SBMA, SLC22A11, SLC22A7, SLC22A8, SMAX1, Seven transmembrane helix receptor, Slc22a1, Solute carrier family 22, Solute carrier family 22 (organic anion transporter) member 6, Solute carrier family 22 (organic anion transporter), member 8, Solute carrier family 22 (organic anion/urate transporter) member 11, Solute carrier family 22 member 1, Solute carrier family 22 member 11, Solute carrier family 22 member 6, Solute carrier family 22 member 7, Solute carrier family 22 member 8, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, TSH Receptor, TSHR_HUMAN, Testicular Feminization (TFM), Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, androgen receptor splice variant 4b, estrogen receptor related receptor alpha, hERR1, hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, hPAHT, hROAT1, hTSHR I, liver specific transporter, oct1_cds, rEP3a, rEP3b, solute carrier family 22 (organic anion transporter) member 7, solute carrier family 22 (organic cation transporter), member 1
MW 352.5 Da, Purity >99%. Potent EP1, EP2, EP3, and EP4 ligand (Kd values are 1 - 10 nM). COX product of arachidonic acid (ab120916). Shows potent vasodilatory and pro-nociceptive effects *in vivo.* 3D Growth matrix component used in liver and prostate organoid generation.
363-24-6
> 99%
Solid
352.5 Da
C20H32O5
5280360
Synthetic
Soluble in ethanol to 100 mM. Soluble in DMSO to 100 mM.
Dinoprostone
Potent EP1, EP2, EP3, and EP4 ligand (Kd values are 1 - 10 nM). COX product of arachidonic acid (ab120916). Shows potent vasodilatory and pro-nociceptive effects *in vivo.* 3D Growth matrix component used in liver and prostate organoid generation.
CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
XEYBRNLFEZDVAW-ARSRFYASSA-N
(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Ambient - Can Ship with Ice
-20°C
-20°C
Store under desiccating conditions, The product can be stored for up to 12 months
This supplementary information is collated from multiple sources and compiled automatically.
The TSH Receptor also known as TSH-R is a pivotal protein in thyroid function. It is a transmembrane receptor with an approximate mass of 90 kDa. This receptor is expressed primarily in thyroid gland cells where it binds to thyroid-stimulating hormone (TSH) to mediate its effects. The GLI3 protein Androgen Receptor and Estrogen Related Receptor alpha are significant targets too; each contributes uniquely to cellular growth regulation. Prostanoid receptors like Prostaglandin E Receptor EP2 (PTGER2) and Prostaglandin F2 alpha Receptor (PTGFR) participate in varying physiological processes. The SLC22 family proteins such as SLC22A6 (OAT3) and SLC22A7 (OAT2) are important for substrate transport across cell membranes.
The TSH Receptor plays a central role in thyroid hormone synthesis and secretion. It activates complex signaling pathways within thyroid cells upon TSH binding leading to the production of triiodothyronine (T3) and thyroxine (T4). The Androgen Receptor is important for mediating the effects of male sex hormones while the Estrogen Related Receptor alpha influences energy metabolism. Prostaglandin E Receptor EP2 (PTGER2) is key for inflammatory responses and vasodilatation. The SLC22 transporters such as OCT1 (SLC22A1) and OAT4 (SLC22A11) manage the translocation of metabolites and xenobiotics affecting pharmacokinetics.
The TSH Receptor is integral to the thyroid hormone biosynthesis pathway. It in coordination with proteins like adenylate cyclase influences cyclic AMP (cAMP) production facilitating downstream effects. The Androgen Receptor interacts within the testosterone signaling pathway directly linked to growth and reproductive processes. Prostaglandin receptors like EP1 EP2 and EP3 subtypes participate in prostaglandin signaling affecting inflammation and vascular function. Components of the SLC22 family such as OAT3 and OAT2 contribute prominently to drug excretion pathways interacting with various transport proteins.
The TSH Receptor's aberrant function is linked to hyperthyroidism and Graves' disease where autoantibodies lead to excess thyroid activity. The Androgen Receptor connections are evident in prostate cancer as it can drive tumor growth in response to androgen. Prostaglandin receptors such as EP2 relate to inflammation-related conditions like arthritis where they mediate pain and swelling through interactions with inflammatory cytokines. Disorders linked to SLC22 transporters like OAT3 include drug-induced nephrotoxicity where impaired excretion leads to toxicity.
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