PS48 (DMSO solution), PDK1 activator

Key facts

CAS number

1180676-32-7

Purity

>95%

Form

Liquid

form

Molecular weight

286.8 Da

Molecular formula

C₁₇H₁₅ClO₂

PubChem

44141940

Nature

Synthetic

Biochemical name

(2z)-5-(4-Chlorophenyl)-3-Phenylpent-2-Enoic Acid

Biological description

Allosteric PDK1 activator. Stimulates PI3-kinase and phosphorylates AKT. Binds to the PIF pocket in the small lobe of PDK1. Shows developmental effects in vivo.

Canonical smiles

C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl

Isomeric smiles

C1=CC=C(C=C1)/C(=C\C(=O)O)/CCC2=CC=C(C=C2)Cl

InChi

InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-

InChiKey

LLJYFDRQFPQGNY-QINSGFPZSA-N

IUPAC Name

(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid