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MW 331.8 Da, Purity >99%. Potent, selective, competitive human A3 receptor antagonist (Ki values are 2.3 nM and 10 μM for human and rat A3 receptors, respectively), Antagonises human A1 and A2A receptors. Shows inverse agonist effects in the [35S]GTPγS binding assay. Shows anti-inflammatory effects.

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Chemical Structure - PSB 11 hydrochloride, competitive human A3 receptor antagonist (AB120995), expandable thumbnail

Publications

Key facts

Purity
> 99%
Form
Solid
Molecular weight
331.8 Da
Molecular formula
C16H18ClN5O
PubChem identifier
16759152
Nature
Synthetic

Target data

Recommended products

MW 331.8 Da, Purity >99%. Potent, selective, competitive human A3 receptor antagonist (Ki values are 2.3 nM and 10 μM for human and rat A3 receptors, respectively), Antagonises human A1 and A2A receptors. Shows inverse agonist effects in the [35S]GTPγS binding assay. Shows anti-inflammatory effects.

Key facts

Purity
> 99%
PubChem identifier
16759152
Solubility

Soluble in DMSO to 25 mM.

Biochemical name
CID 16759152
Biological description

Potent, selective, competitive human A3 receptor antagonist (Ki values are 2.3 nM and 10 μM for human and rat A3 receptors, respectively), Antagonises human A1 and A2A receptors. Shows inverse agonist effects in the [35S]GTPγS binding assay. Shows anti-inflammatory effects.

Canonical SMILES
CCC1CN2C(=N1)C3=C(N=C(N3)C4=CC=CC=C4)N(C2=O)C.Cl
Isomeric SMILES
CC[C@@H]1CN2C(=N1)C3=C(N=C(N3)C4=CC=CC=C4)N(C2=O)C.Cl
InChI
InChI=1S/C16H17N5O.ClH/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10;/h4-8,11H,3,9H2,1-2H3,(H,18,19);1H/t11-;/m1./s1
InChIKey
JAUSHKIWPLHBCN-RFVHGSKJSA-N
IUPAC name
(8R)-8-ethyl-4-methyl-2-phenyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - PSB 11 hydrochloride, competitive human A3 receptor antagonist (ab120995), expandable thumbnail

    Chemical Structure - PSB 11 hydrochloride, competitive human A3 receptor antagonist (ab120995)

    2D chemical structure image of ab120995, PSB 11 hydrochloride, competitive human A3 receptor antagonist

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Product protocols

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