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AB120933

Purmorphamine, Smoothened receptor agonist

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(7 Publications)

MW 520.63 g/mol, Purity >98%. Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells. When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
1 Images
Chemical Structure - Purmorphamine, Smoothened receptor agonist (AB120933)
  • Chemical Structure

Lab

Chemical Structure - Purmorphamine, Smoothened receptor agonist (AB120933)

2D chemical structure image of ab120933, Purmorphamine, Smoothened receptor agonist

Key facts

CAS number

483367-10-8

Purity

>98%

Form

Solid

form

Molecular weight

520.63 g/mol

Molecular formula

C<sub>3</sub><sub>1</sub>H<sub>3</sub><sub>2</sub>N<sub>6</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biological description

Smoothened (Smo) receptor agonist (EC50 ~ 1 μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes and myoblasts into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Canonical smiles

O1CCN(CC1)C1CCC(CC1)NC1NC(OC2CCCC3CCCCC23)NC2C1NCN2C1CCCCC1

IUPAC Name

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

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Complementary Products

Biochemicals

AB142160

SAG (Smo agonist), Smoothened agonist

Chemical Structure - SAG (Smo agonist), Smoothened agonist (AB142160)

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

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Primary Antibodies

AB32572

Anti-beta Catenin antibody [E247] - ChIP Grade

BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [E247] - ChIP Grade (AB32572)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Nature protocols 18:3918-3973 PubMed37985878

2023

Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain.

Applications

Unspecified application

Species

Unspecified reactive species

Mara Zilocchi,Matineh Rahmatbakhsh,Mohamed Taha Moutaoufik,Kirsten Broderick,Alla Gagarinova,Matthew Jessulat,Sadhna Phanse,Hiroyuki Aoki,Khaled A Aly,Mohan Babu

EMBO reports 24:e55571 PubMed36744302

2023

Ubiquitylation of BBSome is required for ciliary assembly and signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Francesco Chiuso,Rossella Delle Donne,Giuliana Giamundo,Laura Rinaldi,Domenica Borzacchiello,Federica Moraca,Daniela Intartaglia,Rosa Iannucci,Emanuela Senatore,Luca Lignitto,Corrado Garbi,Paolo Conflitti,Bruno Catalanotti,Ivan Conte,Antonio Feliciello

Communications biology 4:1071 PubMed34552196

2021

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren Malave,Dustin R Zuelke,Santiago Uribe-Cano,Lev Starikov,Heike Rebholz,Eitan Friedman,Chuan Qin,Qin Li,Erwan Bezard,Andreas H Kottmann

The EMBO journal 40:e106503 PubMed33934390

2021

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

Applications

Unspecified application

Species

Unspecified reactive species

Emanuela Senatore,Francesco Chiuso,Laura Rinaldi,Daniela Intartaglia,Rossella Delle Donne,Emilia Pedone,Bruno Catalanotti,Luciano Pirone,Bianca Fiorillo,Federica Moraca,Giuliana Giamundo,Giovanni Scala,Andrea Raffeiner,Omar Torres-Quesada,Eduard Stefan,Marcel Kwiatkowski,Alienke van Pijkeren,Manuela Morleo,Brunella Franco,Corrado Garbi,Ivan Conte,Antonio Feliciello

Nature communications 11:414 PubMed31964872

2020

Structural insight into small molecule action on Frizzleds.

Applications

Unspecified application

Species

Unspecified reactive species

Paweł Kozielewicz,Ainoleena Turku,Carl-Fredrik Bowin,Julian Petersen,Jana Valnohova,Maria Consuelo Alonso Cañizal,Yuki Ono,Asuka Inoue,Carsten Hoffmann,Gunnar Schulte

Molecular therapy : the journal of the American Society of Gene Therapy 28:452-465 PubMed31866117

2019

Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Se-Ra Park,Soo-Rim Kim,Chan Hum Park,Soyi Lim,Seung Yeon Ha,In-Sun Hong,Hwa-Yong Lee

Molecular therapy : the journal of the American So 27:1286-1298 PubMed31080015

2019

An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2.

Applications

Unspecified application

Species

Unspecified reactive species

Ara Cho,Se-Ra Park,Soo-Rim Kim,Seungyoon Nam,Soyi Lim,Chan Hum Park,Hwa-Yong Lee,In-Sun Hong
View all publications
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