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MW 188.3 Da, Purity >98%. Irreversible, competitive Thioredoxin-1 inhibitor (Ki = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo..

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Images

Chemical Structure - PX 12, Thioredoxin-1 inhibitor (AB146140), expandable thumbnail

Key facts

CAS number
141400-58-0
Purity
> 98%
Form
Solid
Molecular weight
188.3 Da
Molecular formula
C7H12N2S2
PubChem identifier
219104
Nature
Synthetic

Target data

Recommended products

MW 188.3 Da, Purity >98%. Irreversible, competitive Thioredoxin-1 inhibitor (Ki = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo..

Key facts

Purity
> 98%
PubChem identifier
219104
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
2-(Sec-butyldisulfanyl)-1h-imidazole
Biological description

Irreversible, competitive Thioredoxin-1 inhibitor (Ki = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo.

Canonical SMILES
CCC(C)SSC1=NC=CN1
InChI
InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChIKey
BPBPYQWMFCTCNG-UHFFFAOYSA-N
IUPAC name
2-(butan-2-yldisulfanyl)-1H-imidazole

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2217 PX 12. 2217-25 is the same size as the 25 mg size of ab146140.

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1 product image

  • Chemical Structure - PX 12, Thioredoxin-1 inhibitor (ab146140), expandable thumbnail

    Chemical Structure - PX 12, Thioredoxin-1 inhibitor (ab146140)

    2D chemical structure image of ab146140, PX 12, Thioredoxin-1 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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