PX-866, PI3-kinase inhibitor

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MW 525.6 Da, Purity >98%. Potent, irreversible PI3-kinase inhibitor. Inhibits purified phosphoinositide (PtdIns)-3-kinase (IC₅₀ = 0.1 nM) and PtdIns-3-kinase signaling as assessed by phospho-Ser473-Akt levels in HT-29 colon cancer cells (IC₅₀ = 20 nM). Ring-​opened analog of wortmannin (ab120148). Displays antitumor activity.

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5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, CLOVE, CWS5, FK506 binding protein 12 rapamycin associated protein 1, FK506 binding protein 12 rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, FLJ44809, FRAP, FRAP1, FRAP2, KAPCG_HUMAN, KAPG, MCAP, MCM, MCMTC, MGC142161, MGC142163, MTOR_HUMAN, Mammalian target of rapamycin, Mechanistic target of rapamycin, OTTHUMP00000001983, PI 3 Kinase catalytic subunit alpha, PI3 kinase p110 subunit alpha, PI3-kinase subunit alpha, PI3K, PI3K-alpha, PI3KC A, PIK3C A, PK3CA_HUMAN, PKA C-gamma, PKACg, PRKACG, Phosphatidylinositol 3 kinase catalytic alpha polypeptide, Phosphatidylinositol 3 kinase catalytic 110 KD alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha, Phosphatidylinositol-4, Phosphoinositide 3 kinase catalytic alpha polypeptide, Protein kinase cAMP dependent catalytic gamma, PtdIns 3 kinase p110, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit p110-alpha, RAFT1, RAPT1, Rapamycin and FKBP12 target 1, Rapamycin associated protein FRAP2, Rapamycin target protein, Rapamycin target protein 1, Serine (threonine) protein kinase, Serine/threonine protein kinase PIK3CA, Serine/threonine-protein kinase mTOR, cAMP-dependent protein kinase catalytic subunit gamma, caPI3K, dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1), p110 alpha