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MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

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Images

Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (AB141469), expandable thumbnail

Publications

Key facts

CAS number

418805-02-4

Purity

> 98%

Form

Solid

Molecular weight

371.3 Da

Molecular formula

C17H13N3O7

PubChem identifier

5335621

Nature

Synthetic

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MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Key facts

Purity

> 98%

PubChem identifier

5335621

Solubility

Soluble in DMSO to 50 mM.

Biochemical name

Pyr-41

Biological description

Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Canonical SMILES

CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2

Isomeric SMILES

CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2

InChI

InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-

InChIKey

ARGIPZKQJGFSGQ-LCYFTJDESA-N

IUPAC name

ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1925 PYR-41. 1925-25 is the same size as the 25 mg size of ab141469.

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1 product image

  • Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (ab141469), expandable thumbnail

    Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (ab141469)

    2D chemical structure image of ab141469, PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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