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AB141469

PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

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MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.
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Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (AB141469)
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Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (AB141469)

2D chemical structure image of ab141469, PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

Key facts

CAS number

418805-02-4

Purity

>98%

Form

Solid

form

Molecular weight

371.3 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>3</sub>N<sub>3</sub>O<sub>7</sub>

PubChem

5335621

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Pyr-41

Biological description

Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Canonical smiles

CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2

Isomeric smiles

CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2

InChi

InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-

InChiKey

ARGIPZKQJGFSGQ-LCYFTJDESA-N

IUPAC Name

ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1925 PYR-41. 1925-25 is the same size as the 25 mg size of ab141469.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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