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MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

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Images

Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (AB141469), expandable thumbnail

Key facts

CAS number
418805-02-4
Purity
> 98%
Form
Solid
Molecular weight
371.3 Da
Molecular formula
C17H13N3O7
PubChem identifier
5335621
Nature
Synthetic

Target data

Recommended products

MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Key facts

Purity
> 98%
PubChem identifier
5335621
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
Pyr-41
Biological description

Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.

Canonical SMILES
CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
Isomeric SMILES
CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2
InChI
InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChIKey
ARGIPZKQJGFSGQ-LCYFTJDESA-N
IUPAC name
ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 1925 PYR-41. 1925-25 is the same size as the 25 mg size of ab141469.

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1 product image

  • Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (ab141469), expandable thumbnail

    Chemical Structure - PYR-41, Ubiquitin-activating enzyme (E1) inhibitor (ab141469)

    2D chemical structure image of ab141469, PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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