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AB145871

Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator

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(3 Publications)

MW 286.29 Da, Purity >99%. Cell-permeable non-toxic hydrazone iron chelator. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Anticancer and apoptotic agent. Active in vitro.

See similar compounds.
1 Images
Chemical Structure - Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator (AB145871)
  • Chemical Structure

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Chemical Structure - Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator (AB145871)

2D chemical structure image of ab145871, Pyridoxal isonicotinoyl hydrazone (PIH), hydrazone iron chelator

Key facts

CAS number

737-86-0

Purity

>99%

Form

Solid

form

Molecular weight

286.29 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>4</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

135409539

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Pyridoxal isonicotinoyl hydrazone

Biological description

Cell-permeable non-toxic hydrazone iron chelator. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Anticancer and apoptotic agent. Active in vitro.

See similar compounds

Canonical smiles

CC1=NC=C(C(=C1O)C=NNC(=O)C2=CC=NC=C2)CO

Isomeric smiles

CC1=NC=C(C(=C1O)/C=N/NC(=O)C2=CC=NC=C2)CO

InChi

InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,19-20H,8H2,1H3,(H,18,21)/b17-7+

InChiKey

BQYIXOPJPLGCRZ-REZTVBANSA-N

IUPAC Name

N-[(E)-[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methylideneamino]pyridine-4-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1012857 PubMed39899594

2025

Iron-mediated post-transcriptional regulation in Toxoplasma gondii.

Applications

Unspecified application

Species

Unspecified reactive species

Megan A Sloan,Adam Scott,Dana Aghabi,Lucia Mrvova,Clare R Harding

eLife 10: PubMed33526170

2021

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jumpei Ito,Shigemiki Omiya,Mara-Camelia Rusu,Hiromichi Ueda,Tomokazu Murakawa,Yohei Tanada,Hajime Abe,Kazuki Nakahara,Michio Asahi,Manabu Taneike,Kazuhiko Nishida,Ajay M Shah,Kinya Otsu

Cell reports 30:3250-3260.e7 PubMed32160534

2020

Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels.

Applications

Unspecified application

Species

Unspecified reactive species

Miriam Hernández-Morales,Trisha Shang,Jingjia Chen,Victor Han,Chunlei Liu
View all publications
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