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AB144501

Pyrimidyn-7™, dynamin inhibitor

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(4 Publications)

MW 363.59 g/mol, Purity >97%. Novel, potent dual action dynamin inhibitor (IC50 values are 1.1 and 1.8 µM at dynamin I and II respectively). Only inhibitor to target two distinct domains of dynamin.
Competitively inhibits both GTP and phospholipid binding. Reversibly inhibits clathrin mediated endocytosis (CME) and synaptic vesicle endocytosis (SVE) in nerve terminals.

Key facts

CAS number

1440126-94-2

Purity

>97%

Form

Liquid

form

Molecular weight

363.59 g/mol

Nature

Synthetic

Biological description

Novel, potent dual action dynamin inhibitor (IC50 values are 1.1 and 1.8 µM at dynamin I and II respectively). Only inhibitor to target two distinct domains of dynamin.
Competitively inhibits both GTP and phospholipid binding. Reversibly inhibits clathrin mediated endocytosis (CME) and synaptic vesicle endocytosis (SVE) in nerve terminals.

Canonical smiles

CN(C)CCNC1NC(C)CC(NCCCCCCCCCCCC)N1

InChi

InChI=1S/C21H41N5/c1-5-6-7-8-9-10-11-12-13-14-15-22-20-18-19(2)24-21(25-20)23-16-17-26(3)4/h18H,5-17H2,1-4H3,(H2,22,23,24,25)

InChiKey

CKRZZHPNUCLRBE-UHFFFAOYSA-N

IUPAC Name

N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine

50 mM
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Complementary Products

Biochemicals

AB120689

Dyngo® 4a highly potent dynamin inhibitor

Chemical Structure - Dyngo® 4a highly potent dynamin inhibitor (AB120689)

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Biochemicals

AB120687

Pitstop® 2, cell-permeable clathrin inhibitor

Chemical Structure - Pitstop® 2, cell-permeable clathrin inhibitor (AB120687)

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Biochemicals

AB144290

Latrunculin A (LAT-A), Actin polymerization inhibitor

Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (AB144290)

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Biochemicals

AB120192

Dynasore, dynamin inhibitor

Immunocytochemistry/ Immunofluorescence - Dynasore, dynamin inhibitor (AB120192)

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Product details

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pyrimidyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Biology of the cell 115:e2300001 PubMed37095727

2023

Dynamin-2 controls actin remodeling for efficient complement receptor 3-mediated phagocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Mularski,Ryszard Wimmer,Floriane Arbaretaz,Gabriel Le Goff,Manon Depierre,Florence Niedergang

eLife 10: PubMed33527898

2021

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Hadeel Alyenbaawi,Richard Kanyo,Laszlo F Locskai,Razieh Kamali-Jamil,Michèle G DuVal,Qing Bai,Holger Wille,Edward A Burton,W Ted Allison

Cells 9: PubMed32842657

2020

Role of Jagged1-mediated Notch Signaling Activation in the Differentiation and Stratification of the Human Limbal Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Sheyla González,Maximilian Halabi,David Ju,Matthew Tsai,Sophie X Deng

eLife 6: PubMed28498105

2017

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development.

Applications

Unspecified application

Species

Unspecified reactive species

Max van Lessen,Shannon Shibata-Germanos,Andreas van Impel,Thomas A Hawkins,Jason Rihel,Stefan Schulte-Merker
View all publications
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