AB141588

QNZ, NF-kB inhibitor

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(8 Publications)

MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo..

1 Images

Chemical Structure - QNZ, NF-kB inhibitor (AB141588)

Chemical Structure

Lab

Chemical Structure - QNZ, NF-kB inhibitor (AB141588)

2D chemical structure image of ab141588, QNZ, NF-kB inhibitor

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

358.4 Da

Molecular formula

C22H22N4O

PubChem

35026803

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Soluble in ethanol to 25 mM

Biochemical name

N4-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine

Biological description

Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo.

Canonical smiles

C1NC2=C(C=C(C=C2)N)C(=N1)NCCC3=CC=C(C=C3)OC4=CC=CC=C4

InChi

InChI=1S/C22H22N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14,25H,12-13,15,23H2,(H,24,26)

InChiKey

GGBVTWRQPMDRCK-UHFFFAOYSA-N

IUPAC Name

4-N-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 587:216724 PubMed38373689

2024

CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Divya Murthy,Debasmita Dutta,Kuldeep S Attri,Tagari Samanta,Sukjin Yang,Kwang Hwa Jung,Sarah G Latario,Vasanta Putluri,Shixia Huang,Nagireddy Putluri,Jun Hyoung Park,Benny Abraham Kaipparettu

Anais da Academia Brasileira de Ciencias 95:e20220596 PubMed37132750

2023

Nuclear Factor-Kappa B-induced miRNA-518a-5p represses trophoblast cell migration and invasion by the Nuclear Factor-Kappa B pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Peng,Ruirui Zhang,Yumei Zhang,Chunyan Cai

Antioxidants (Basel, Switzerland) 12: PubMed36671037

2023

Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuyun Liu,Jing Gao,Yizhen Yan,Eleftheria A Georgiou,Jing Lou,Mengya Feng,Xing Zhang,Feng Gao,Jiankang Liu,Ioannis K Kostakis,Lin Zhao

Journal of innate immunity 14:629-642 PubMed35613551

2022

Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils.

Applications

Unspecified application

Species

Unspecified reactive species

Yadu Balachandran,Sarah Caldwell,Gurpreet Kaur Aulakh,Baljit Singh

Experimental physiology 105:1708-1719 PubMed32770578

2020

Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis.

Applications

Unspecified application

Species

Unspecified reactive species

Pingying Qing,Yi Liu

Experimental and therapeutic medicine 20:2577-2584 PubMed32765751

2020

Prazosin blocks apoptosis of endothelial progenitor cells through downregulating the Akt/NF-κB signaling pathway in a rat cerebral infarction model.

Applications

Unspecified application

Species

Unspecified reactive species

Shudong Liu,Wenyan Li

Life sciences 255:117849 PubMed32473249

2020

Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhu,Aichen Sun,Taocheng Meng,Haolan Li

Journal of cellular and molecular medicine 24:7609-7624 PubMed32441055

2020

Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Jian Xi,Jin Jiang Zeng,Yong Lu,Shao Hua Chen,Zhi Wen Jiang,Peng Jie He,Hua Mi

View all publications

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QNZ, NF-kB inhibitor

Chemical Structure - QNZ, NF-kB inhibitor (AB141588)

Key facts

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (8)

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Product promise