MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC50 = 11 nM). Inhibits LPS-induced TNFα production (IC50 = 7 nM). Reduces edema in inflammation in vivo..
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- Anais da Academia Brasileira de Ciencias 95:e202205962023Nuclear Factor-Kappa B-induced miRNA-518a-5p represses trophoblast cell migration and invasion by the Nuclear Factor-Kappa B pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXing Peng,Ruirui Zhang,Yumei Zhang,Chunyan CaiPubMed 37132750
- Antioxidants (Basel, Switzerland) 12:2023Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuyun Liu,Jing Gao,Yizhen Yan,Eleftheria A Georgiou,Jing Lou,Mengya Feng,Xing Zhang,Feng Gao,Jiankang Liu,Ioannis K Kostakis,Lin ZhaoPubMed 36671037
- Journal of innate immunity 14:629-6422022Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYadu Balachandran,Sarah Caldwell,Gurpreet Kaur Aulakh,Baljit SinghPubMed 35613551
- Experimental physiology 105:1708-17192020Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPingying Qing,Yi LiuPubMed 32770578
- Experimental and therapeutic medicine 20:2577-25842020Prazosin blocks apoptosis of endothelial progenitor cells through downregulating the Akt/NF-κB signaling pathway in a rat cerebral infarction model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShudong Liu et. al.PubMed 32765751
- Life sciences 255:1178492020Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Zhu et. al.PubMed 32473249
- Journal of cellular and molecular medicine 24:7609-76242020Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao Jian Xi et. al.PubMed 32441055
Key facts
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 358.4 Da
- Molecular formula
- C22H22N4O
- PubChem identifier
- 35026803
- Nature
- Synthetic
Target data
Recommended products
MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC50 = 11 nM). Inhibits LPS-induced TNFα production (IC50 = 7 nM). Reduces edema in inflammation in vivo..
Key facts
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 358.4 Da
- Molecular formula
- C22H22N4O
- PubChem identifier
- 35026803
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 50 mM.
Soluble in ethanol to 25 mM.
- Biochemical name
- N4-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine
- Biological description
Potent, selective NF-kB inhibitor (IC50 = 11 nM). Inhibits LPS-induced TNFα production (IC50 = 7 nM). Reduces edema in inflammation in vivo.
- Canonical SMILES
- C1NC2=C(C=C(C=C2)N)C(=N1)NCCC3=CC=C(C=C3)OC4=CC=CC=C4
- InChI
- InChI=1S/C22H22N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14,25H,12-13,15,23H2,(H,24,26)
- InChIKey
- GGBVTWRQPMDRCK-UHFFFAOYSA-N
- IUPAC name
- 4-N-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - QNZ, NF-kB inhibitor (ab141588)
2D chemical structure image of ab141588, QNZ, NF-kB inhibitor
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